Parathyroid gland
Secondary chief cell hyperplasia

Topic Completed: 1 January 2013

Minor changes: 6 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Secondary chief cell hyperplasia

Monika Roychowdhury, M.D.
Page views in 2019: 402
Page views in 2020 to date: 128
Cite this page: Roychowdhury M. Secondary chief cell hyperplasia. website. Accessed May 28th, 2020.
Definition / general
  • Gland may be normal sized with microscopic hypercellularity or be grossly enlarged
  • Hyperplasia due to reduced mean serum calcium level
  • "Secondary" is based on historical, chemical and laboratory findings (not due to primary alteration in PTH)
Microscopic (histologic) images

Images hosted on other servers:

Enlarged glands due to chronic renal failure with impaired phosphate excretion

Differential diagnosis
  • Adenoma: rim of normal, nonhyperplastic tissue around the mass and at least one normal parathyroid gland
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