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Parathyroid gland


Secondary chief cell hyperplasia

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Gland may be normal sized with microscopic hypercellularity or be grossly enlarged
● Hyperplasia due to reduced mean serum calcium level
● “Secondary” is based on historical, chemical and laboratory findings (not due to primary alteration in PTH)

Micro images

Enlarged glands due to chronic renal failure with impaired phosphate excretion

Differential diagnosis

Adenoma: rim of normal, non-hyperplastic tissue around the mass and at least one normal parathyroid gland

End of Parathyroid gland > Hyperparathyroidism > Secondary chief cell hyperplasia

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