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Parathyroid gland


Water clear cell hyperplasia

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 17 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Extreme enlargement of all parathyroid tissue with weights up to 100g; causes primary hyperparathyroidism
● Incidence has decreased over past 20 years, now very rare
● No familial incidence, not associated with MEN (unlike chief cell hyperplasia)
● Associated with blood group O (Hum Genet 1994;94:195)

Gross description

● Superior glands larger than inferior glands
● 2 giant glands may appear as one
● Soft, chocolate-brown, with cysts and hemorrhages
● Pseudopods also common

Micro description

● Abundant optically clear cells of variable size (hyperplasia and hypertrophy), with spherical clear vacuoles surrounded by thin eosinophilic material; basal nuclei, compact or alveolar patterns

Micro images

Water clear cell hyperplasia

End of Parathyroid gland > Hyperparathyroidism > Water clear cell hyperplasia

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