Penis & scrotum
Mesenchymal tumors

Topic Completed: 1 May 2010

Minor changes: 20 August 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Leiomyosarcoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
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Cite this page: Chaux A, Cubilla AL. Leiomyosarcoma. website. Accessed September 23rd, 2020.
Definition / general
  • Malignant tumor similar to their counterparts elsewhere in the body
  • ICD-O: 8890 / 3
  • Mean age 51 years, range 43 - 62 years
  • Very rare, < 50 cases reported but still second most common sarcoma of penis after Kaposi sarcoma
  • Usually shaft or base of penis but can occur at any site
Clinical features
  • More likely to be superficial (above tunica albuginea) than deep seated
  • Often recurs locally
  • Superficial lesions are asymptomatic, deep seated lesions may cause dysuria or difficulty voiding
Prognostic factors
Case reports
  • Wide local excision if superficial, excision as necessary for complete removal of deeper tumors
Gross description
  • Median 1.5 cm (range 0.5 - 6.0 cm), often superficial
  • White-tan-gray, firm tumor with irregular borders
Microscopic (histologic) description
  • Interlacing fascicles of spindle cells with abundant eosinophilic cytoplasm, focal juxtanuclear vacuoles and blunt ended nuclei
  • Atypia ranges from moderate to severe
  • Occasionally atypical multinucleated giant cells, focal necrosis
  • Mitoses easily found and can be numerous
Microscopic (histologic) images

Images hosted on other servers:

Cigar shaped nuclei

Involving corpora cavernosa

Smooth muscle actin

Differential diagnosis
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