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Penis and scrotum
Squamous cell carcinoma and variants
Squamous cell carcinoma - NOS

Reviewer: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Reviewers page)
Revised: 9 July 2013, last major update May 2010
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Case reports
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Gross description
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Gross images
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Exophytic cauliflower-like mass has effaced the glans, which is extensively involved by a multinodular mass with focal ulceration

Circumcision specimen shows a flat, granular, beige
neoplasm involving mucosa of the foreskin but not the skin


Red-tan ulcerated tumor

Fungating mass


Nodular white tumor
extensively involves sulcus

Massive involvement of the glans,
coronal sulcus and foreskin


Autoamputation of penis

Massive involvement caused multiple foci of
ulceration of foreskin in an uncircumcised man


Extensive squamous cell carcinoma in situ

Focal infiltration of the corpus spongiosum


Solid yellow-tan neoplasm

Superficial, white, serrated papillary and
tan, solid, deeply invasive components


Four separate foci present

Cobblestone appearance representing condyloma (top)


Micro description
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Micro images
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Grade 1

Grade 2

Grade 3


Finger-like projections into dermis

Vascular invasion

Measuring depth of invasion


Low grade keratinizing (A, B); moderate to high-grade nonkeratinizing (C); high-grade nonkeratinizing tumor (D); and carcinoma with prominent glycogenated clear cells (E)


Mucosa involved by carcinoma at the top
and uninvolved epidermis at the bottom


Contributed by Dr. Alcides Chaux and Dr. Antonio Cubilla:

Usual type: well-differentiated (left, grade 1); moderately differentiated (middle, grade 2); poorly differentiated (right, grade 3)

Mixed (hybrid) usual-verrucous carcinoma


Virtual slides
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Squamous cell carcinoma of penis

Differential diagnosis
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End of Penis and scrotum > Squamous cell carcinoma and variants > Squamous cell carcinoma - NOS


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