Penis & scrotum
Mesenchymal tumors
Aggressive angiomyxoma

Topic Completed: 1 May 2010

Minor changes: 7 August 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Aggressive angiomyxoma scrotum

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2019: 670
Page views in 2020 to date: 392
Cite this page: Chaux A, Cubilla AL. Aggressive angiomyxoma. website. Accessed September 28th, 2020.
Definition / general
Clinical features
Case reports
Clinical images

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Marked swelling

Scrotal mass

Gross description
  • Irregular and infiltrative borders
  • Gelatinous, mucoid cut surface
  • Tumor size 3 - 60 cm (usually > 5 cm)
Gross images

Contributed by Dr. J. C. Iezzoni

Ill defined mass

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Gelatinous cut surface

Microscopic (histologic) description
  • Hypocellular, stellate / spindle stromal cells with delicate cytoplasmic processes
  • Prominent myxoid (mucicarmine positive) to collagenous stroma
  • Abundant small to medium sized blood vessels, many with hypertrophy / hyalinization (Am J Surg Pathol 1992;16:1059)
  • Extravasation of erythrocytes is common
  • No atypia or significant mitotic activity
Microscopic (histologic) images

AFIP images

Delicate vessels and myxoid stroma

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Thick walled vessels, myxoid to collagenous stroma



Prominent myxoid stroma

Spermatic cord:

Spindle cells

Variable sized vessels

Perivascular spindled cells



Scattered PR+

Vulvar tumor

Negative stains
Molecular / cytogenetics description
Differential diagnosis
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