Penis and scrotum
Neoplastic lesions of scrotum
Aggressive angiomyxoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 9 April 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Aggressive angiomyxoma scrotum

Cite this page: Cubilla, A., Chaux, A. Aggressive angiomyxoma. website. Accessed October 18th, 2018.
Definition / general
Clinical features
Case reports
Clinical images

Images hosted on other servers:

Marked swelling

Scrotal mass

Gross description
  • Irregular and infiltrative borders
  • Gelatinous, mucoid cut surface
  • Tumor size 3 - 60 cm (usually > 5 cm)
Gross images

Images hosted on other servers:

Gelatinous cut surface

Ill defined mass

Microscopic (histologic) description
  • Hypocellular, stellate / spindle stromal cells with delicate cytoplasmic processes
  • Prominent myxoid (mucicarmine positive) to collagenous stroma
  • Abundant small to medium sized blood vessels, many with hypertrophy / hyalinization (Am J Surg Pathol 1992;16:1059)
  • Extravasation of erythrocytes is common
  • No atypia or significant mitotic activity
Microscopic (histologic) images

Images hosted on PathOut server:

Delicate vessels and myxoid stroma

Images hosted on other servers:

Thick walled vessels, myxoid to collagenous stroma



Prominent myxoid stroma

Spermatic cord:

Spindle cells

Variable sized vessels

Perivascular spindled cells



Scattered PR+

Vulvar tumor

Negative stains
Molecular / cytogenetics description
Differential diagnosis