Penis and scrotum
Other malignancies
Basal cell carcinoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 5 April 2018, last major update April 2010

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Basal cell carcinoma penis

Cite this page: Cubilla, A., Chaux, A. Basal cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotumbcc.html. Accessed October 15th, 2018.
Definition / general
Epidemiology
  • Very rare
Sites
  • Most cases arise in skin of shaft, may be multicentric
Etiology
  • No evidence of HPV infection
  • Typically develops on sun exposed skin and is closely associated with ultraviolet radiation
Clinical features
  • Usually ages 40+ years (J Urol 1994;152:1557)
  • Slowly growing hyperpigmented tumor
  • Risk factors include ultraviolet and ionizing radiation, arsenic ingestion, immunosuppression and inherited syndromes, such as nevoid basal cell carcinoma syndrome and xeroderma pigmentosum
  • Extremely low metastatic potential (J Am Acad Dermatol 2001;45:68)
Prognostic factors
  • Multicentric and large tumors may present more aggressive behavior
Case reports
Treatment
  • Excision
Clinical images

Images hosted on other servers:

Ulcer almost circumscribing penis and causing penis / scrotal edema

Microscopic (histologic) description
  • Regular neoplastic nests with evident peripheral palisading
  • No areas of central comedonecrosis
  • Frequent myxoid stromal changes
Microscopic (histologic) images

Images hosted on PathOut server:

Skin - not necessarily penis



Images hosted on other servers:

Skin - not necessarily penis

Differential diagnosis
  • Basaloid carcinoma: involves glans not shaft, more pleomorphic neoplastic cells, frequent central comedonecrosis and absence of peripheral palisading