Penis and scrotum - Basal cell carcinoma

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Penis and scrotum

Other malignancies

Basal cell carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Editor: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)

Revised: 30 April 2010, last major update April 2010

Definition

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● Similar to counterpart in skin (see Skin-Nonmelanocytic Tumor chapter)

● ICD-0: 8090/3

Epidemiology

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● Very rare

Sites

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● Most cases arise in skin of shaft, may be multicentric

Etiology

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● No evidence of HPV infection

● Typically develops on sun-exposed skin and is closely associated with ultraviolet radiation

Clinical features

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● Usually ages 40+ years (J Urol 1994;152:1557)

● Slowly-growing hyperpigmented tumor

● Risk factors include ultraviolet and ionizing radiation, arsenic ingestion, immunosuppression, and inherited syndromes such as nevoid basal cell carcinoma syndrome and xeroderma pigmentosum

● Extremely low metastatic potential (J Am Acad Dermatol 2001;45:68)

Prognostic factors

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● Multicentric and large tumors may present more aggressive behavior

Case reports

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● 75 year old man with multicentric tumor with skin metastases (Scand J Plast Reconstr Surg Hand Surg 2002;36:180)

Treatment

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● Excision

Clinical images

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Ulcer almost circumscribing penis and causing penis / scrotal edema

Micro description (Histopathology)

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● Regular neoplastic nests with evident peripheral palisading

● No areas of central comedonecrosis

● Frequent myxoid stromal changes

Micro images

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Skin-not necessarily penis

Differential Diagnosis

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● Basaloid carcinoma: involves glans not shaft, more pleomorphic neoplastic cells, frequent central comedonecrosis, absence of peripheral palisading

End of Penis and scrotum > Other malignancies > Basal cell carcinoma

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