Penis and scrotum
Other malignancies
Clear cell carcinoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 5 April 2018, last major update April 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Clear cell carcinoma penis

Cite this page: Cubilla, A., Chaux, A. Clear cell carcinoma. website. Accessed November 14th, 2018.
Definition / general
  • Recently described aggressive variant of penile carcinoma
  • Middle aged men
  • Foreskin inner mucosa
  • Most likely of sweat gland origin
  • HPV 16 DNA found in all reported cases
Clinical features
  • All reported patients presented with inguinal nodal metastases with clear cells and sclerotic basement membrane material
Case reports
  • Excision with wide surgical margin
Gross description
  • Large, exophytic and partially ulcerated
  • Size 2.5 - 5.5 cm
Microscopic (histologic) description
  • Solid proliferation of large neoplastic clear cells
  • Marked nuclear atypia
  • Extensive geographical necrosis
  • Angiolymphatic invasion is common
  • Warty PeIN may be found at surface
Positive stains
Differential diagnosis