Penis and scrotum
Neoplastic lesions of scrotum
Desmoplastic round cell tumor

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 2 October 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Desmoplastic round cell tumor scrotum

See also: Testis chapter
Cite this page: Cubilla, A., Chaux, A. Desmoplastic round cell tumor. website. Accessed October 17th, 2018.
Definition / general
Clinical features
  • Poor prognosis at all sites, with frequent death from disease
Case reports
  • Surgery plus chemotherapy
Gross description
  • Multinodular, firm, bulky tumor with smooth bosselated surfaces
  • Cut surface is gray-white with sharply demarcated areas of necrosis / hemorrhage
Gross images

Images hosted on PathOut server:

Contributed by Dr. J. Prat, Barcelona, Spain:

Tunica vaginalis is
distended and studded
by a gray-white mass

Images hosted on other servers:

Various images - site unspecified

Microscopic (histologic) description
  • Irregular, sharply demarcated clusters of small round cells embedded in a dense fibrous / fibromyxoid stroma
  • Neoplastic cells are undifferentiated, with small round to oval hyperchromatic nuclei with inconspicuous nucleoli and scant cytoplasm
  • Foci of necrosis are common, especially in larger tumor nests
  • Areas of more pleomorphic, atypical, epithelioid or spindle cells are seen in 1/3 of cases
  • Occasionally rhabdoid cells, signet ring-like cells and tubular-like structures
Microscopic (histologic) images

Images hosted on PathOut server:

Nests of cells with
scant cytoplasm in
desmoplastic stroma

Images hosted on other servers:

Scrotal metastasis

Various images - sites unspecified

Cytology images

Images hosted on other servers:

Site unspecified - small round blue cells

Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis