Penis and scrotum - Grossing penectomy specimens

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Penis and scrotum

Miscellaneous

Grossing penectomy specimens

Editors: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)

Revised: 13 May 2010, last major update May 2010

Procedure

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● Fix the whole specimen in 10% buffered formalin overnight

● When fixed, section the specimen in two halves using the meatus and anterior urethra as a guide

● Do NOT probe the urethra

● If foreskin is not affected by tumor, separate it leaving a 3 mm margin from coronal sulcus and include it as a circumcision specimen

● If foreskin is affected by tumor, do NOT remove it

● Take a photograph or make a diagram of the specimen, focusing on the tumoral invasion of anatomical levels

● Section each half longitudinally along the specimen’s longest axis, at 3 to 5 mm intervals

● Take a photograph (or make a diagram) and submit entirely the section which depicts the deepest anatomical level infiltrated by tumor

● If tumor affects multiple anatomical compartments, submit at least three sections of each compartment affected

● Sections should always include adjacent non tumoral mucosa

● Resection margins in partial penectomies are urethra and periurethral tissues, corpora cavernosa and skin of shaft; they should be entirely submitted

Gross images

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Diagram of periurethral Squamous cell carcinoma (ca, yellow)

corpus spongiosum involvement involves the corpora cavernosa, with

by carcinoma (yellow), u: urethra; greater left sided involvement;

cc: corpora cavernosa; fas: Buck’s fascia urethra (u) is uninvolved, a: tunica

albuginea; cs: corpus spongiosum

Partial penectomy specimen shows extensive involvement by carcinoma, including Buck’s fascia, at the resection margin (top right), bf: Buck’s fascia; f: foreskin; lp: lamina propria; cs: corpus spongiosum; cc: corpus cavernosum

Additional references

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● Eur Urol 2004;46:434, Am J Surg Pathol 2001; 25:1091

End of Penis and scrotum > Miscellaneous > Grossing penectomy specimens

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