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Penis and scrotum
Non-neoplastic lesions of scrotum
Idiopathic calcinosis
Editors: Antonio Cubilla, M.D. and Alcides Chaux, M.D.
Revised: 15 May 2010, last major update May 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Uncommon disorder characterized by presence of calcified nodules in scrotal skin
Epidemiology
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● 2/3 patients are young adults
● Lesions appear first in childhood or early adulthood
Etiology
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● Dystrophic calcification of epidermal cysts (Dermatol Online J 2010;16:5)
Clinical features
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● Slow-growing, painless masses, may extensively involve scrotum (Urology 2010 Apr 8 [Epub ahead of print])
● Discharge of white chalky material
Gross description (Macroscopy)
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● Size varies from a few millimeters to several centimeters
● Nodular, bosselated masses
Clinical images
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52 year old man Various images
Micro description (Histopathology)
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● Granules and globules of basophilic calcified material in scrotal dermis
● Foreign body giant-cell reaction is common
● Remnants of epidermal cysts seen in some cases
Micro images
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Calcification in scrotal soft tissue
Foreign body giant cell reaction
Calcification of H&E and Calcium stain
preexisting cyst
Cytology description
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● Amorphous calcific masses and granules (J Cytol 2008;25:23)
Cytology images
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FNA smear
Differential Diagnosis
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● Dystrophic calcification due to Onchocerca volvulus: presence of parasite in tissue sections
End of Penis and scrotum > Non-neoplastic lesions of scrotum > Idiopathic calcinosis
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