Penis and scrotum
Neoplastic lesions of scrotum

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 10 April 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Leiomyoma scrotum

Cite this page: Cubilla, A., Chaux, A. Leiomyoma. website. Accessed October 17th, 2018.
Definition / general
  • Rare in scrotum, similar to counterpart elsewhere
  • ICD-O: 8890 / 0
  • Classified as leiomyoma cutis (originates in skin) or dartoic leiomyoma (originates in tunica dartos)
  • Scrotal leiomyoma cutis can be further subclassified as pilar leiomyoma (originates in adnexal smooth muscle) or angioleiomyoma (originates in vascular smooth muscle)
Clinical features
  • May clinically resemble a cyst
  • Firm to hard rubbery painless mass
  • Rarely polypoid or ulcerated
  • Epithelioid features, myxoid change and hyalinization are much less common than in vulvar lesions (Histopathology 1991;18:523)
  • Conservative; local excision
Gross description
  • Tumor size 0.2 - 3.0 cm
Gross images

Images hosted on other servers:

Tan-gray cut surface

Microscopic (histologic) description
  • Circumscribed, nonencapsulated proliferation of spindle shaped cells with smooth muscle features arranged in fascicles
  • Smooth muscle fascicles separated by variably collagenized stroma
  • Bizarre, atypical and symplastic changes in some cases (see leiomyoma with bizarre nuclei)
  • Rarely myxoid changes and lymphoid aggregates
  • No necrosis, no / rare mitoses
  • Overlying skin is without epithelial alterations
Microscopic (histologic) images

Images hosted on PathOut server:

Leiomyoma of dartos has smooth muscle bundles separated by collagenous stroma

Images hosted on other servers:

Bundles and fascicles of smooth muscle cells with eosinophilic fibrillar cytoplasm and elongated nuclei with blunted ends

Well circumscribed tumor

Interlacing bundles

Positive stains