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Penis and scrotum
Other malignancies
Primary Lymphoma
Editor: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)
Revised: 25 May 2010, last major update – April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Primary penile lymphomas are exceedingly rare
● Secondary involvement is somewhat common in disseminated disease
Sites
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● All penile compartments may be affected
Clinical features
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● Non-Hodgkin B or T cell lymphoma is more common than Hodgkin lymphoma
● Confirmation and phenotyping is done by immunohistochemistry
Case reports
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● 65 year old man with primary peripheral T cell lymphoma of penis (Zhonghua Nan Ke Xue 2008;14:1003)
● MALT lymphoma of foreskin (Leuk Lymphoma 2004;45:1699)
Treatment
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● Recommended to avoid radiation therapy, which has severe side effects (Acta Haematol 2008;120:150)
Clinical images
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A 5 cm ulcer of the dorsum of the penis Post-chemotherapy, ulcer shows marked resolution.
There was no evidence of recurrence at 2 years follow up
Gross description (Macroscopy)
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● Fleshy white neoplasm, nonspecific ulceration
Gross images
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Irregular, shaggy, white-gray mass of the dorsal
foreskin and extensively involving the glans
Micro description (Histopathology)
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● Dense infiltrate of atypical lymphocytes
Micro images
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Large cell lymphoma
Differential Diagnosis
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● Extramammary Paget’s disease: positive for MUC1, MUC5a, CAM 5.2, CEA, EMA; negative for lymphocyte markers
End of Penis and scrotum > Other malignancies > Primary Lymphoma
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