Penis and scrotum
Nonneoplastic lesions of scrotum
Massively localized lymphedema in morbidly obese patients

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 9 April 2018, last major update May 2010

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Massive localized lymphedema obese

Cite this page: Cubilla, A., Chaux, A. Massively localized lymphedema in morbidly obese patients. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotummassiveedema.html. Accessed October 20th, 2018.
Definition / general
  • Benign tumor-like condition affecting the scrotum
Terminology
  • Type of localized massive lymphedema
Sites
  • Scrotum, also thigh, popliteal fossa, abdomen, suprapubic and inguinal region
Etiology
  • Obstruction of efferent lymphatic drainage by either massive abdominal pannus (usually patients weigh > 250 pounds) or prior surgery
  • Associated with hypothyroidism (Hum Pathol 2000;31:1162)
Clinical features
  • Huge mass resembling neoplasm (mean 50 cm, range 38 - 75 cm), of 9 months to 18 years duration
Gross description
  • Poorly defined, nonencapsulated
  • Skin indurated with peau d'orange appearance
  • Marbled appearance with fibrous bands intersecting adipose tissue lobules
Gross images

Images hosted on PathOut server:

Massive scrotal edema

Microscopic (histologic) description
  • Lobules of adipose tissue intersected by fibrous bands
  • Lymphatic vascular ectasia, chronic inflammatory infiltrates, fibrosis, edema between collagen fibers, infarction and fat necrosis
  • May have floret-like giant cells or smooth muscle hyperplasia (Int J Surg Pathol 2011;19:212)
Microscopic (histologic) images

Images hosted on other servers:

Figure 7 (not from scrotum)

Differential diagnosis