Penis and scrotum
Neoplastic lesions of scrotum
Mesothelioma (malignant) of scrotum

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 2 October 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Mesothelioma malignant scrotum

See also: Testis chapter
Cite this page: Cubilla, A., Chaux, A. Mesothelioma (malignant) of scrotum. website. Accessed October 17th, 2018.
Definition / general
  • Microscopic, immunohistochemical and ultrastructural features similar to mesothelioma of pleura
  • ICD-O: 9050 / 3
  • Benign scrotal / paratesticular mesothelial lesions include mesothelial cyst, reactive mesothelial hyperplasia, adenomatoid tumor, benign cystic mesothelioma and benign papillary mesothelioma
  • Exceedingly rare (less common than tumors of pleura and peritoneum)
  • Most occur between ages 55 - 75 years
  • Arises from mesothelial cells that line tunica vaginalis or tunica albuginea
  • Asbestos exposure in < 50%
Clinical features
  • Often resembles a hydrocele
  • May have coexisting pleural or peritoneal tumors
  • Very aggressive - infiltrates adjacent tissue or metastasizes to retroperitoneal lymph nodes
Case reports
Gross description
  • Thickening of tunica vaginalis with multiple nodules
  • Variable involvement of tunica albuginea
Gross images

Images hosted on PathOut server:

Tunica vaginalis

Images hosted on other servers:

Multiple soft tissue nodules

Yellowish white contents

Microscopic (histologic) description
  • Usually epithelioid, pure sarcomatoid is rare
  • Patterns are papillary, tubular or solid
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Electron microscopy description
  • Long, thin microvilli