Penis and scrotum
Other malignancies
Metastases to penis


Topic Completed: 1 May 2010

Revised: 14 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Metastases[TI] penis[TI]
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Cite this page: Chaux A, Cubilla AL. Metastases to penis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotummetastases.html. Accessed May 19th, 2019.
Definition / general
  • Secondary penile involvement by malignant tumors that originate elsewhere
Epidemiology
  • Mean age 67 years (range 53 - 79 years)
Sites
  • Mainly penile shaft; rarely glans and foreskin
Etiology
  • Primaries usually have GU origin (mainly prostate and urinary bladder) followed by GI (mainly colon - rectum) and respiratory system (Int J Surg Pathol 2011;19:597)
  • Other primary sites are rare
Clinical features
  • Usually presents with a tumor mass
  • Priapism in 27 - 40% of all cases
  • Rarely pain, hematuria and impaired urination
  • Most metastases are metachronous (not simultaneous) with a known primary, with an interval of 16 months (range 3 - 60 months) between primary and metastases
  • Mean survival 18 months from primary treatment and 5 months after diagnosis of penile metastasis
Clinical images

AFIP images

Metastatic carcinoma in lamina propria

Small nodules are seen in the coronal sulcus



Images hosted on other servers:

Urothelial carcinoma of renal pelvis

Gross description
  • Ill defined, usually multicentric, tumor mass
  • Tumor size varies from millimeters to 4 cm
Gross images

AFIP images

Massive obliteration

Tan-white solid tumor tissue

Distortion of tunica albuginea

Multiple discrete tumor masses

Microscopic (histologic) description
  • Microscopic features of primary tumor retained in most cases
  • Tumor emboli permeate vascular spaces of erectile tissues, mainly corpora cavernosa
  • Tumor foci may also be found in lamina propria, penile fascia or skin
Microscopic (histologic) images

AFIP images

Tumor cells plug periurethral blood vessels

Tumor cells line corpus cavernosum vessels

Massive involvement of erectile tissue

Tumor replaces
much of the
corpora cavernosa
at autopsy

Two nodules of metastatic colonic adenocarcinoma



Images hosted on other servers:

Urothelial carcinoma of renal pelvis

Metastatic prostatic carcinoma is PSA+

Cytology images

Images hosted on other servers:

Metastatic urothelial carcinoma of bladder

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