Penis and scrotum
Inflammatory lesions
Peyronie disease

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 2 April 2018, last major update February 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Peyronie disease[TI]

Cite this page: Cubilla, A., Chaux, A. Peyronie disease. website. Accessed October 15th, 2018.
Definition / general
  • Dense focal fibrosis of dermis and Buck fascia of penile shaft between corpora cavernosa and tunica albuginea, usually causing curvature towards side of lesion and restricting movement of these structures during erection
  • Also called "induratio penis plastica"
  • Considered a variant of superficial fibromatosis which preferentially affects the tunica albuginea
  • May be related to microtrauma (coital, urethral instrumentation), which releases fibroblast related cytokines
  • May arise secondary to urethritis as a sclerosing inflammatory process
Clinical features
  • May be associated with carcinoid syndrome, Dupuytren contracture
  • May be associated with beta blockers, thiazides (J Sex Med 2010;7:1529), hypertension, diabetes and immune reactions
  • Fibrosis produces an abnormal curvature of the penis, which may cause pain during erection and intercourse
  • In some cases, nodules adherent to tunica albuginea are noted over the mid dorsal line
  • May be clinically mimicked by epithelioid sarcoma (Int J Impot Res 2003;15:378)
Case reports
Clinical images

Images hosted on PathOut server:

AFIP images:

Images hosted on other servers:

Various images


Gross description
  • Irregular areas of fibrosis in dermis and fascia of penile shaft, mainly related to and in contact with tunica albuginea
  • Occasionally nodular areas of fibrosis may predominate
Gross images

Images hosted on PathOut server:

AFIP images:

Tunica albuginea
surrounding both
corpora cavernosa
is thickened

Microscopic (histologic) description
  • Dense fibrous nodules, similar to those in Dupuytren contracture, fibromatosis and other desmoplastic conditions involving myofibroblasts
  • More dense and less cellular than other types of superficial fibromatosis
  • Perivascular lymphoid infiltrate in early stages of disease
  • Fibrotic tunica albuginea with extension of fibrosis to corpus cavernosum
  • Abnormal vessels with venous leakages
  • Calcification or ossification may occur
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Whole mount shows
focal thickening of
tunica albuginea
and calcification

Superficial fibromatosis - other sites:

Mitotic figures
may be present
in cellular regions
but are never atypical

Nodule of variably cellular fibroblastic tissue