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Penis and scrotum
Infectious disorders
Plasma cell balanitis
Reviewers: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)
Revised: 21 February 2010, last major update February 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Inflammatory condition with prominent plasma cells
Terminology
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● Also known as balanitis circumscripta plasmacellularis, Zoon’s balanitis
● Balanitis: inflammation of glans
Epidemiology
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● Middle-aged and elderly uncircumcised men
Etiology
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● Etiology unknown, but probably reactive
Clinical features
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● Disease tends to be chronic and may persist for months to years
● Solitary or rarely multiple brown red plaques located in glans or inner foreskin
● Surface is shiny, slightly moist and stippled with minute red specks
● May simulate erythroplasia of Queyrat / Bowen’s disease
Case reports
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● Middle aged man with erythroplasia of Queyrat and coexisting plasma cell balanitis (Int J STD AIDS 2008;19:861)
Treatment
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● Circumcision (J Cutan Med Surg 2006;10:11), laser excision, topical antibiotics or steroids; possibly pimecrolimus 1% cream (Int J Dermatol 2008;47:198)
Clinical images
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Rash on distal shaft AFIP Fig 10-71: glans mucosa is extensively involved by erythematous lesion
resembling erythroplasia of Queyrat
Micro description (Histopathology)
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● Epidermal atrophy, band like infiltrate of plasma cells in dermis, hemosiderin pigment laden macrophages (siderophages), edema, numerous capillaries
● Epithelium may show mild reactive changes which can simulate penile intraepithelial neoplasia
● Rarely plasma cells are scant/absent
Micro images
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Low power High power
Additional references
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End of Penis and scrotum > Infectious disorders > Plasma cell balanitis
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