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Penis and scrotum
Neoplastic lesions of scrotum
Posttraumatic spindle cell nodule of scrotum
Editors: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)
Revised: 23 May 2010, last major update May 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● More common in urinary bladder, rarely reported in scrotum
Terminology
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● Also called post-operative spindle cell nodule
Epidemiology
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● Wide age range
Etiology
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● Trauma related tumor-like lesion
Clinical features
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● Circumscribed mass or diffuse progressive enlargement of scrotal wall
● Arises weeks to months after surgery or trauma
● No recurrence after local excision
Case reports
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● 22 and 67 year old men with scrotal lesions secondary to trauma (Archives 1994;118:709)
Micro description (Histopathology)
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● Monomorphic, dense, spindle cell proliferations forming irregular nodules in wall of hematoma
● Dense collagenous matrix
● Low mitotic rate and no cytological atypia
Micro images
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Bladder
Myofibroblastic cells and inflammatory L: muscularis propria, R: spindle cell nodule
cells in myxoid stroma
Fascicular growth Highly cellular with Keratin+ Actin+
numerous mitoses
AFIP Fig 2-70: interlacing fascicles Uniform cells are mixed with
of myofibroblasts inflammatory cells
Positive stains
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● Smooth muscle markers (desmin, smooth muscle actin)
Molecular / cytogenetics
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● Trisomy 7 identified at other sites (Cancer Genet Cytogenet 2007;174:147)
Differential Diagnosis
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● Leiomyosarcoma: more cellular, atypical cells, high mitotic rate
End of Penis and scrotum > Neoplastic lesions of scrotum > Posttraumatic spindle cell nodule of scrotum
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