Penis and scrotum
Squamous cell carcinoma and variants
Pseudoglandular carcinoma


Topic Completed: 1 April 2010

Revised: 13 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Pseudoglandular carcinoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2018: 311
Page views in 2019 to date: 604
Cite this page: Chaux A, Cubilla AL. Pseudoglandular carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotumsccpseudoglandular.html. Accessed December 7th, 2019.
Definition / general
  • Unusual and aggressive variant of penile carcinoma with pseudoglands, often filled with amorphous material
Terminology
  • Also called adenoid or acantholytic carcinoma
Epidemiology
  • Average 54 years
Sites
  • Glans, coronal sulcus and inner foreskin are usually involved
Clinical features
  • Higher metastatic rate and cancer related deaths when compared with usual SCC
Case reports
Gross description
  • Large, irregular white-gray ulcerative or exophytic masses
  • Frequent invasion of deep erectile tissues
  • Average size 4.6 cm
Microscopic (histologic) description
  • Hallmark is the pseudogland: open space lined by atypical, cubical or cylindrical uni or multistratified cells
  • Pseudoglands frequently filled with amorphous material containing debris, keratin and desquamated cells
  • Intraluminal neutrophilic microabscesses are not uncommon
  • Frequent presence of intracytoplasmic clear vacuoles, sometimes with a collaret arrangement
  • Variegated tumor aspect showing solid areas intermingled with pseudoglandular spaces
  • Frequent vascular and perineural invasion
Microscopic (histologic) images

Contributed by Alcides Chaux, M.D.
and Antonio Cubilla, M.D.

Simulating glandular lumina

Irregular tumor nests



Penis:

Pseudoglandular carcinoma



Images hosted on other servers:

Conjunctiva:

Acantholysis of neoplastic squamous cells


Head and neck:

Pseudolumina are present but no true glands


Skin:

Various images

Negative stains
Differential diagnosis
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