Penis and scrotum
Squamous cell carcinoma and variants
Warty basaloid carcinoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 5 April 2018, last major update May 2010

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Warty basaloid carcinoma penis

Cite this page: Cubilla, A., Chaux, A. Warty basaloid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotumsccwartybasaloid.html. Accessed December 15th, 2018.
Definition / general
  • Recently described variant of penile carcinoma composed of mixed features of warty and basaloid carcinomas showing > 10% of either warty or basaloid component
Epidemiology
Sites
  • Glans, coronal sulcus and especially inner foreskin
  • Most tumors invade multiple anatomical compartments
Etiology
  • Most cases are HPV+
Clinical features
  • More aggressive than pure warty carcinoma but less than basaloid carcinoma
  • Inguinal nodal metastasis in 50% of patients
  • 5 and 10 year survival rates of 69% and 61% respectively
  • Mean survival time of 2.8 years (Mod Pathol 2010;23:896)
  • Cancer specific mortality rate of 33%
Prognostic factors
  • Higher proportions of basaloid cells are associated with more aggressive behavior
  • Tumors invading deeper and with perineural invasion show a higher metastatic rate
Gross description
  • White-gray irregular mass ranging from exophytic to endophytic
  • Mean size 5.5 cm (range 2 - 12 cm)
  • Frequent invasion of deep erectile tissues
Microscopic (histologic) description
  • Areas of warty carcinoma intermingled with others showing basaloid features
  • Areas of basaloid carcinoma usually predominate
  • Frequent vascular and perineural invasion
  • PeIN in adjacent areas with basaloid or warty features

Patterns of growth:
  • Typical condylomatous tumor on surface and deep infiltrative nests with basaloid features (most common pattern)
  • Nonpapillomatous invasive nests exhibiting central warty features and peripheral basaloid aspect
  • Predominantly papillomatous with papillae composed of central basaloid cells and peripheral warty features
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Alcides Chaux, M.D. and Antonio Cubilla, M.D.

Peripheral basaloid cells and central clear cells

Exophytic tumor with papillae lined by cells

Differential diagnosis