Penis and scrotum
Squamous cell carcinoma and variants
Warty basaloid carcinoma


Topic Completed: 1 May 2010

Revised: 13 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Warty basaloid carcinoma penis
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Cite this page: Chaux A, Cubilla AL. Warty basaloid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/penscrotumsccwartybasaloid.html. Accessed May 19th, 2019.
Definition / general
  • Recently described variant of penile carcinoma composed of mixed features of warty and basaloid carcinomas showing > 10% of either warty or basaloid component
Epidemiology
Sites
  • Glans, coronal sulcus and especially inner foreskin
  • Most tumors invade multiple anatomical compartments
Etiology
  • Most cases are HPV+
Clinical features
  • More aggressive than pure warty carcinoma but less than basaloid carcinoma
  • Inguinal nodal metastasis in 50% of patients
  • 5 and 10 year survival rates of 69% and 61% respectively
  • Mean survival time of 2.8 years (Mod Pathol 2010;23:896)
  • Cancer specific mortality rate of 33%
Prognostic factors
  • Higher proportions of basaloid cells are associated with more aggressive behavior
  • Tumors invading deeper and with perineural invasion show a higher metastatic rate
Gross description
  • White-gray irregular mass ranging from exophytic to endophytic
  • Mean size 5.5 cm (range 2 - 12 cm)
  • Frequent invasion of deep erectile tissues
Microscopic (histologic) description
  • Areas of warty carcinoma intermingled with others showing basaloid features
  • Areas of basaloid carcinoma usually predominate
  • Frequent vascular and perineural invasion
  • PeIN in adjacent areas with basaloid or warty features

Patterns of growth:
  • Typical condylomatous tumor on surface and deep infiltrative nests with basaloid features (most common pattern)
  • Nonpapillomatous invasive nests exhibiting central warty features and peripheral basaloid aspect
  • Predominantly papillomatous with papillae composed of central basaloid cells and peripheral warty features
Microscopic (histologic) images

Contributed by Alcides Chaux, M.D. and Antonio Cubilla, M.D.

Peripheral basaloid cells and central clear cells

Exophytic tumor with papillae lined by cells

Differential diagnosis
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