Penis and scrotum
Other malignancies
Sclerosing epithelioid fibrosarcoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 6 April 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Sclerosing epithelioid fibrosarcoma penis

Cite this page: Cubilla, A., Chaux, A. Sclerosing epithelioid fibrosarcoma. website. Accessed October 18th, 2018.
Definition / general
  • Middle age men
  • Penile root
Clinical features
  • Large tumors
Microscopic (histologic) description
  • Small to moderate size, round to ovoid, relatively uniform epithelioid cells and often with clear cytoplasm
  • Prominent deeply eosinophilic sclerotic collagenous bands of different thickness between epithelioid nests and cords
  • Epithelioid cells arranged in single files, cords, nests and irregularly shaped sheets
  • Epithelioid cells have bland nuclei with slight pleomorphism
  • Occasional spindle cells
  • Fibroma-like and myxoid areas in some cases
  • Necrosis occasionally seen, usually focal and microscopic
  • Variable mitotic rate
  • No giant or multinucleated tumor cells
Microscopic (histologic) images

Images hosted on PathOut server:

Ankle mass

Images hosted on other servers:

Cecal tumor

Sacral tumor

Keratin MNF 116

Positive stains
Negative stains
Electron microscopy description
  • Cytoplasmic features of fibroblasts
Differential diagnosis
  • Other primary penile sarcomas: less prominent or absent sclerotic matrix, pattern of immunohistochemistry