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Penis and scrotum
Other malignancies
Sclerosing epithelioid fibrosarcoma
Editor: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)
Revised: 22 May 2010, last major update May 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Fibrosarcoma of soft parts composed predominantly of epithelioid cells
● Penile location is exceedingly rare (Am J Surg Pathol 2001;25:699)
Epidemiology
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● Middle age men
Sites
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● Penile root
Clinical features
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● Large tumors
Micro description (Histopathology)
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● Small to moderate-size, round to ovoid, relatively uniform epithelioid cells, often with clear cytoplasm
● Prominent deeply eosinophilic sclerotic collagenous bands of different thickness between epithelioid nests and cords
● Epithelioid cells arranged in single files, cords, nests and irregularly shaped sheets
● Epithelioid cells have bland nuclei with slight pleomorphism
● Occasional spindle cells
● Fibroma-like and myxoid areas in some cases
● Necrosis occasionally seen, usually focal and microscopic
● Variable mitotic rate
● No giant or multinucleated tumor cells
Micro images
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Ankle mass Cecal tumor Sacral tumor
Single file pattern
Keratin MNF 116
Positive stains
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● Vimentin (strong, diffuse)
Negative stains
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● Usually CAM 5.2, AE1/AE3, S100, HHF-35, smooth muscle actin, CD34
Electron microscopy descriptions
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● Cytoplasmic features of fibroblasts
Differential Diagnosis
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● Other primary penile sarcomas: less prominent or absent sclerotic matrix, pattern of immunohistochemistry
End of Penis and scrotum > Other malignancies > Sclerosing epithelioid fibrosarcoma
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