Penis and scrotum
Other malignancies
Sclerosing epithelioid fibrosarcoma

Topic Completed: 1 May 2010

Revised: 14 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Sclerosing epithelioid fibrosarcoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2018: 82
Page views in 2019 to date: 153
Cite this page: Chaux A, Cubilla AL. Sclerosing epithelioid fibrosarcoma. website. Accessed November 13th, 2019.
Definition / general
  • Middle age men
  • Penile root
Clinical features
  • Large tumors
Microscopic (histologic) description
  • Small to moderate size, round to ovoid, relatively uniform epithelioid cells and often with clear cytoplasm
  • Prominent deeply eosinophilic sclerotic collagenous bands of different thickness between epithelioid nests and cords
  • Epithelioid cells arranged in single files, cords, nests and irregularly shaped sheets
  • Epithelioid cells have bland nuclei with slight pleomorphism
  • Occasional spindle cells
  • Fibroma-like and myxoid areas in some cases
  • Necrosis occasionally seen, usually focal and microscopic
  • Variable mitotic rate
  • No giant or multinucleated tumor cells
Microscopic (histologic) images

Case of the Week #3

Ankle mass

Images hosted on other servers:

Cecal tumor

Sacral tumor

Keratin MNF 116

Positive stains
Negative stains
Electron microscopy description
  • Cytoplasmic features of fibroblasts
Differential diagnosis
  • Other primary penile sarcomas: less prominent or absent sclerotic matrix, pattern of immunohistochemistry
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