Penis and scrotum
Neoplastic lesions of scrotum
Squamous cell carcinoma of scrotum

Topic Completed: 1 May 2010

Revised: 15 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Squamous cell carcinoma[TIAB] scrotum

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2019: 755
Page views in 2020 to date: 104
Cite this page: Chaux A, Cubilla AL. Squamous cell carcinoma of scrotum. website. Accessed February 20th, 2020.
Definition / general
  • Most common type of primary scrotal cancer
  • Mean age 62 years
  • Dramatic decrease in incidence in U.S. in past 50 years
Risk factors:
  • Occupational exposure: chimney sweeps, paraffin workers, tar workers, cotton mill workers, machine operators in engineering, screw making workers, automatic lathe operators, petroleum wax pressmen and truck drivers
  • Poor hygiene
  • PUVA treatment, radiotherapy
  • HPV infection in about 50% of cases
Staging / staging classifications

Lowe staging (J Urol 1983;130:423):
A1:Localized to scrotum
A2:Locally extensive involving adjacent structures, including testis, spermatic cord, penis, pubic bone or perineum
B:Metastases to inguinal lymph nodes
C:Metastases to pelvic lymph nodes
D:Metastases to distant organs
Clinical features
  • Solitary, slow growing lesion and frequently ulcerated
  • Left side and anterolateral aspect of scrotum in occupational cases
  • Nodal metastases present in 50% of enlarged inguinal nodes
Case reports
  • Wide local excision with bilateral lymphadenectomy
Clinical images

AFIP images

Tumor at junction of scrotum and penis

Contributed by Dr. S. F. Cramer, Rochester, New York

Large bosselated mass

Images hosted on other servers:

Scrotal ulcer and warts

Gross description
  • Red plaque or white-gray granular lesion
  • Rarely has exophytic growth
Microscopic (histologic) description
  • Most cases are well to moderately differentiated squamous cell carcinoma of the usual type
  • Verrucous, sarcomatoid, warty, basaloid and papillary variants may be seen
  • Scrotal intraepithelial neoplasia frequently found
Microscopic (histologic) images

Contributed by Dr. A. Cubilla, Paraguay

Well, moderately and poorly differentiated tumors

Images hosted on other servers:

Perineural invasion

Epididymis histology

Carcinoma in situ

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