Penis and scrotum
Neoplastic lesions of scrotum
Squamous cell carcinoma of scrotum

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 10 April 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Squamous cell carcinoma[TIAB] scrotum

Cite this page: Cubilla, A., Chaux, A. Squamous cell carcinoma of scrotum. website. Accessed October 18th, 2018.
Definition / general
  • Most common type of primary scrotal cancer
  • Mean age 62 years
  • Dramatic decrease in incidence in U.S. in past 50 years
Risk factors:
  • Occupational exposure: chimney sweeps, paraffin workers, tar workers, cotton mill workers, machine operators in engineering, screw making workers, automatic lathe operators, petroleum wax pressmen and truck drivers
  • Poor hygiene
  • PUVA treatment, radiotherapy
  • HPV infection in about 50% of cases
Staging / staging classifications

Lowe staging (J Urol 1983;130:423):
A1:Localized to scrotum
A2:Locally extensive involving adjacent structures, including testis, spermatic cord, penis, pubic bone or perineum
B:Metastases to inguinal lymph nodes
C:Metastases to pelvic lymph nodes
D:Metastases to distant organs
Clinical features
  • Solitary, slow growing lesion and frequently ulcerated
  • Left side and anterolateral aspect of scrotum in occupational cases
  • Nodal metastases present in 50% of enlarged inguinal nodes
Case reports
  • Wide local excision with bilateral lymphadenectomy
Clinical images

Images hosted on PathOut server:

AFIP images:

Tumor at junction of scrotum and penis

Contributed by Dr. S. F. Cramer, Rochester, New York:

Large bosselated mass

Images hosted on other servers:

Scrotal ulcer and warts

Gross description
  • Red plaque or white-gray granular lesion
  • Rarely has exophytic growth
Microscopic (histologic) description
  • Most cases are well to moderately differentiated squamous cell carcinoma of the usual type
  • Verrucous, sarcomatoid, warty, basaloid and papillary variants may be seen
  • Scrotal intraepithelial neoplasia frequently found
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. A. Cubilla, Paraguay:

Well, moderately and poorly differentiated tumors

Images hosted on other servers:

Perineural invasion

Epididymis histology

Carcinoma in situ