Penis and scrotum
Squamous cell carcinoma and variants
Verruciform carcinoma

Authors: Antonio Cubilla, M.D., Alcides Chaux, M.D. (see Authors page)

Revised: 5 April 2018, last major update May 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Verruciform carcinoma penis

See also: cuniculatum, giant condyloma, papillary, verrucous, warty carcinoma
Cite this page: Cubilla, A., Chaux, A. Verruciform carcinoma. website. Accessed December 15th, 2018.
Definition / general
  • Penile exophytic tumors with verruciform gross appearance and low / intermediate grade papillomatous features
  • Either condylomatous (giant condyloma, warty carcinoma) or noncondylomatous (verrucous carcinoma, papillary NOS carcinoma, carcinoma cuniculatum)
  • Variable incidence of HPV infection
Diagrams / tables

Images hosted on PathOut server:


Clinical features
  • Low incidence of regional metastasis and better outcome than usual carcinoma
  • Biopsies may be unable to determine histologic type (Int J Surg Pathol 2004;12:139)
Gross description
  • Usually large tumors with a cauliflower-like aspect
  • May present a predominant exophytic or a mixed exophytic endophytic pattern of growth
Microscopic (histologic) description
  • Papillae with mild to marked acanthosis
  • Hyperkeratosis and parakeratosis
  • May have prominent, irregular or inconspicuous fibrovascular cores
  • Variable HPV related cytopathic changes (koilocytosis)
  • Tumor front may be broad based or jagged
  • Stromal reaction is usually evident