Penis and scrotum
Squamous cell carcinoma and variants
Verruciform carcinoma

Topic Completed: 1 May 2010

Revised: 13 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Verruciform carcinoma penis

See Also: cuniculatum, giant condyloma, papillary, verrucous, warty carcinoma

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2018: 290
Page views in 2019 to date: 468
Cite this page: Chaux A, Cubilla AL. Verruciform carcinoma. website. Accessed November 13th, 2019.
Definition / general
  • Penile exophytic tumors with verruciform gross appearance and low / intermediate grade papillomatous features
  • Either condylomatous (giant condyloma, warty carcinoma) or noncondylomatous (verrucous carcinoma, papillary NOS carcinoma, carcinoma cuniculatum)
  • Variable incidence of HPV infection
Diagrams / tables

AFIP images


Clinical features
  • Low incidence of regional metastasis and better outcome than usual carcinoma
  • Biopsies may be unable to determine histologic type (Int J Surg Pathol 2004;12:139)
Gross description
  • Usually large tumors with a cauliflower-like aspect
  • May present a predominant exophytic or a mixed exophytic endophytic pattern of growth
Microscopic (histologic) description
  • Papillae with mild to marked acanthosis
  • Hyperkeratosis and parakeratosis
  • May have prominent, irregular or inconspicuous fibrovascular cores
  • Variable HPV related cytopathic changes (koilocytosis)
  • Tumor front may be broad based or jagged
  • Stromal reaction is usually evident
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