Gestational trophoblastic disease

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 19 October 2017, last major update December 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Gestational trophoblastic disease[title] placenta

Table of Contents
Definition / general | Treatment
Cite this page: Ziadie, M. Gestational trophoblastic disease - general. website. Accessed November 15th, 2018.
Definition / general
  • Tumors (hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor) and tumor-like lesions (exaggerated placental site, placental site nodule) that are related to trophoblastic proliferation
  • Tumors are rare (1/1000 pregnancies)
  • Women at the extremes of reproductive age are at greatest risk for complete hydatidiform mole
  • Traditional anatomic staging is not a useful prognostic indicator
  • Poor prognostic indicators include duration > 4 months, pretreatment hCG > 40,000, brain or liver metastases, gestational trophoblastic disease (GTD) after term gestation and failed therapy
  • Recurrence / metastases is diagnosed with serum hCG

NIH classification:
  • Benign
  • Malignant, nonmetastatic
  • Malignant, metastatic
  • Methotrexate has cure rates near 100%, even in metastatic disease