Gestational trophoblastic disease

Topic Completed: 1 December 2011

Revised: 21 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Gestational trophoblastic disease[title] placenta

Mandolin S. Ziadie, M.D.
Page views in 2018: 1,657
Page views in 2019 to date: 1,563
Table of Contents
Definition / general | Treatment
Cite this page: Ziadie MS. Gestational trophoblastic disease - general. website. Accessed September 17th, 2019.
Definition / general
  • Tumors (hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor) and tumor-like lesions (exaggerated placental site, placental site nodule) that are related to trophoblastic proliferation
  • Tumors are rare (1/1000 pregnancies)
  • Women at the extremes of reproductive age are at greatest risk for complete hydatidiform mole
  • Traditional anatomic staging is not a useful prognostic indicator
  • Poor prognostic indicators include duration > 4 months, pretreatment hCG > 40,000, brain or liver metastases, gestational trophoblastic disease (GTD) after term gestation and failed therapy
  • Recurrence / metastases is diagnosed with serum hCG

NIH classification:
  • Benign
  • Malignant, nonmetastatic
  • Malignant, metastatic
  • Methotrexate has cure rates near 100%, even in metastatic disease
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