Placental findings in specific newborn / fetal or maternal conditions
Systemic lupus erythematosus

Topic Completed: 1 November 2011

Revised: 19 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Systemic lupus erythematosus[title] placenta

Mandolin S. Ziadie, M.D.
Page views in 2019: 208
Page views in 2020 to date: 32
Cite this page: Ziadie MS. Systemic lupus erythematosus. website. Accessed February 27th, 2020.
Definition / general
  • Maternal autoimmune disease that is associated with a high rate of fetal death and growth restriction
  • Vascular changes and abnormal implantation, possibly due to antiphospholipid antibodies, may lead to vascular occlusion
  • Decreased perfusion and subsequent placental infarction / growth restriction / fetal demise
Case reports
  • Marked decidual vasculopathy and villous infarction in first trimester missed abortion in SLE patient with anticardiolipin antibodies and serum lupus anticoagulant (Hum Pathol 1996;27:201)
Gross description
  • Varies; ranges from normal to infarcted
Microscopic (histologic) description
  • Varies; ranges from normal to extensive infarction
  • Decidual vasculopathy / atherosis may be present and are associated with antiphospholipid antibodies (Obstet Gynecol 2003;101:258)
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