Placental findings in specific newborn / fetal or maternal conditions
Systemic lupus erythematosus

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 16 October 2017, last major update November 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Systemic lupus erythematosus[title] placenta

Cite this page: Ziadie, M. Systemic lupus erythematosus. website. Accessed October 22nd, 2018.
Definition / general
  • Maternal autoimmune disease that is associated with a high rate of fetal death and growth restriction
  • Vascular changes and abnormal implantation, possibly due to antiphospholipid antibodies, may lead to vascular occlusion
  • Decreased perfusion and subsequent placental infarction / growth restriction / fetal demise
Case reports
  • Marked decidual vasculopathy and villous infarction in first trimester missed abortion in SLE patient with anticardiolipin antibodies and serum lupus anticoagulant (Hum Pathol 1996;27:201)
Gross description
  • Varies; ranges from normal to infarcted
Microscopic (histologic) description
  • Varies; ranges from normal to extensive infarction
  • Decidual vasculopathy / atherosis may be present and are associated with antiphospholipid antibodies (Obstet Gynecol 2003;101:258)