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Placenta

Specific Fetal and Maternal Conditions

Systemic Lupus Erythematosus


Reviewers: Mandolin Ziadie, M.D., (see Reviewers page)
Revised: 12 November 2011, last major update November 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Maternal autoimmune disease that is associated with a high rate of fetal death and growth restriction
● Vascular changes and abnormal implantation, possibly due to antiphospholipid antibodies, may lead to vascular occlusion
● Decreased perfusion and subsequent placental infarction / growth restriction / fetal demise

Case reports
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● Marked decidual vasculopathy and villous infarction in first trimester missed abortion in SLE patient with anticardiolipin antibodies and serum lupus anticoagulant (Hum Pathol 1996;27:201)

Gross description (Macroscopy)
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● Varies; ranges from normal to infarcted

Micro description (Histopathology)
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● Varies; ranges from normal to extensive infarction
● Decidual vasculopathy / atherosis may be present and are associated with anti-phospholipid antibodies (Obstet Gynecol 2003;101:258)

End of Placenta > Specific Fetal and Maternal Conditions > Systemic Lupus Erythematosus


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