Placenta - Systemic Lupus Erythematosus

Home Chapter Home Jobs Conferences Fellowships Books

Placenta

Specific Fetal and Maternal Conditions

Systemic Lupus Erythematosus

Reviewers: Mandolin Ziadie, M.D., (see Reviewers page)
Revised: 12 November 2011, last major update November 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Maternal autoimmune disease that is associated with a high rate of fetal death and growth restriction
● Vascular changes and abnormal implantation, possibly due to antiphospholipid antibodies, may lead to vascular occlusion
● Decreased perfusion and subsequent placental infarction / growth restriction / fetal demise

Case reports
=========================================================================

● Marked decidual vasculopathy and villous infarction in first trimester missed abortion in SLE patient with anticardiolipin antibodies and serum lupus anticoagulant (Hum Pathol 1996;27:201)

Gross description (Macroscopy)
=========================================================================

● Varies; ranges from normal to infarcted

Micro description (Histopathology)
=========================================================================

● Varies; ranges from normal to extensive infarction
● Decidual vasculopathy / atherosis may be present and are associated with anti-phospholipid antibodies (Obstet Gynecol 2003;101:258)

End of Placenta > Specific Fetal and Maternal Conditions > Systemic Lupus Erythematosus

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).