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Placenta

Infectious and Inflammatory Conditions

Acute Villitis


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
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● Usually due to ascending infection from vaginal tract, causes premature rupture of membranes
● Associated with prematurity and sepsis in first days of life
● Present in 5-25% of placentas
● Associated with hemorrhagic vasculitis, vascular obliteration
● Not due to meconium staining, which does not directly cause inflammation

Causes
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● Usually associated with E. coli and Group B strep

Grading
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● Mild (<5% of villi)
● Moderate (5-25%)
● Severe (25%+)

Micro description
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● Neutrophils in the fetal capillaries and distal villi
● Organisms are often visible

End of Placenta > Infectious and Inflammatory Conditions > Acute villitis


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