Infectious conditions
Acute villitis

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 11 October 2017, last major update September 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Placenta acute villitis

Cite this page: Ziadie, M. Acute villitis. website. Accessed June 24th, 2018.
Definition / general
  • Usually due to ascending infection from vaginal tract, causes premature rupture of membranes
  • Associated with prematurity and sepsis in first days of life
  • Present in 5 - 25% of placentas
  • Associated with hemorrhagic vasculitis, vascular obliteration
  • Not due to meconium staining, which does not directly cause inflammation
  • Usually associated with E. coli and group B strep
  • Mild ( < 5% of villi)
  • Moderate (5 - 25%)
  • Severe (25%+)
Microscopic (histologic) description
  • Neutrophils in the fetal capillaries and distal villi
  • Organisms are often visible