Placental findings in specific newborn / fetal or maternal conditions
Blighted ovum

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 16 October 2017, last major update October 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Blighted ovum placenta

Cite this page: Ziadie, M. Blighted ovum. website. Accessed November 15th, 2018.
Definition / general
  • Failure of development or early embryonic demise with persistent trophoblast development, leading to an anembryonic gestation
Microscopic (histologic) description
  • Villous stromal edema without central cistern formation or trophoblastic hyperplasia
  • Features of karyotypic abnormalities may be present
  • 52% are trisomic (smaller villi without cisterns), 20% are triploid (resemble partial moles with focal trophoblastic invaginations, cisterns, irregular surfaces and dysmorphic features) and 15% are XO and 6% are tetraploid
  • Before week 8, aneuploidy is most common with embryonic growth disorganization