Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 26 January 2013, last major update September 2011
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● Non-expansile vascular proliferation similar to chorangioma but occurring in otherwise normal stem villi
● Associated with preeclampia, multiple gestation, premature delivery at 32 to 26 weeks (Hum Pathol 2000;31:945)
● Diffuse multifocal subtype asssociated with extreme prematurity (< 32 weeks), congenital malformations, intrauterine growth restriction, delayed villous maturation, avascular villi and placentomegaly
● Proliferation of small capillaries surrounded by a continuous layer of pericytes and stromal fibrosis
● Occurs within the stem villi and does not form a discrete mass
● Focal: involves <5 contiguous villi
● Segmental: involves >5 contiguous villi
● Diffuse / multifocal: involves several non-contiguous areas of the placenta
End of Placenta > Non-Trophoblastic Neoplasms > Chorangiomatosis
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