Nontrophoblastic neoplasms

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 19 October 2017, last major update September 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chorangiomatosis

Cite this page: Ziadie, M. Chorangiomatosis. website. Accessed October 19th, 2017.
Definition / general
  • Nonexpansile vascular proliferation similar to chorangioma but occurring in otherwise normal stem villi
  • Associated with preeclampia, multiple gestation, premature delivery at 32 to 26 weeks (Hum Pathol 2000;31:945)
  • Diffuse multifocal subtype asssociated with extreme prematurity (< 32 weeks), congenital malformations, intrauterine growth restriction, delayed villous maturation, avascular villi and placentomegaly
Microscopic (histologic) description
  • Proliferation of small capillaries surrounded by a continuous layer of pericytes and stromal fibrosis
  • Occurs within the stem villi and does not form a discrete mass
  • Focal: involves < 5 contiguous villi
  • Segmental: involves > 5 contiguous villi
  • Diffuse / multifocal: involves several noncontiguous areas of the placenta