Placenta
Infectious conditions
Chronic intervillositis (massive chronic intervillositis)

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 11 October 2017, last major update September 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Chronic intervillositis OR massive chronic intervillositis

Cite this page: Ziadie, M. Chronic intervillositis (massive chronic intervillositis). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentachronicintervillositis.html. Accessed October 17th, 2017.
Definition / general
Gross description
  • Small placenta
Microscopic (histologic) description
  • Diffuse infiltrate of histiocytes within intervillous space with villous fibrinoid deposits
  • Other associated lesions may include atherosis, acute chorioamnionitis and rarely chronic villitis
  • Malaria: associated with abundant fibrin, black pigment, occasional neutrophils and parasite laden red blood cells
Positive stains
  • CD68 (histiocytic marker)
Negative stains
  • hCG (may be present in syncytiotrophoblasts but marked reduction compared to usual)