Placental gross/microscopic abnormalities, non-neoplastic
Confined placental mosaicism
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update September 2011
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● Mosaicism (combination of cells with different chromosomal content) confined to placenta and not affecting baby
● Diagnosed when discrepant results are seen between chorionic villus sampling and amniocentesis / fetal testing (for example, trisomy 16 is seen in the preliminary chorionic villus sampling results, but the delivered child has a normal karyotype)
● Diagnosed in approximately 2% of pregnancies that undergo chorionic villus sampling; may be associated with fetal growth retardation (J Gynecol Obstet Biol Reprod (Paris) 2002;31:2S70)
● Results from mitotic non-disjunction in a trophoblastic / non-fetal cell leading to trisomy in the placental trophoblasts or stroma, or from trisomic rescue of a fetus without rescue of the placental cell line
End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Confined placental mosaicism
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