Placental gross / microscopic abnormalities, nonneoplastic
Confined placental mosaicism

Topic Completed: 1 September 2011

Minor changes: 15 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Confined placental mosaicism [title]

Mandolin S. Ziadie, M.D.
Page views in 2019: 385
Page views in 2020 to date: 172
Table of Contents
Definition / general | Etiology
Cite this page: Ziadie MS. Confined placental mosaicism. website. Accessed June 1st, 2020.
Definition / general
  • Mosaicism (combination of cells with different chromosomal content) confined to placenta and not affecting baby
  • Diagnosed when discrepant results are seen between chorionic villus sampling and amniocentesis / fetal testing (for example, trisomy 16 is seen in the preliminary chorionic villus sampling results but the delivered child has a normal karyotype)
  • Diagnosed in approximately 2% of pregnancies that undergo chorionic villus sampling; may be associated with fetal growth retardation (J Gynecol Obstet Biol Reprod (Paris) 2002;31:2S70)
  • Results from mitotic nondisjunction in a trophoblastic / nonfetal cell leading to trisomy in the placental trophoblasts or stroma or from trisomic rescue of a fetus without rescue of the placental cell line
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