Placenta - Fetal neurologic impairment / cerebral palsy

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Placenta

Placental findings in specific newborn/fetal or maternal conditions

Fetal neurologic impairment / cerebral palsy

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 13 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Various placental lesions are associated with neurologic impairment; the risk of impairment is increased with the number of lesions present (Arch Pathol Lab Med 2000;124:1785)
● Cerebral thrombi and infarcts may be present (Hum Pathol 1997;28:246)
● Presence of thrombi may indicate a coagulopathy in parents

Micro description
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● Placental lesions independently associated with neurologic impairment include severe fetal chorioamnionitis, diffuse chorioamnionic hemosiderosis and extensive avascular villi
● Also chorionic vessel thrombi, increased nucleated red blood cells, retroplacental hematoma, meconium-associated vascular necrosis, diffuse chronic villitis, perivillous fibrin, non-occulsive thrombi of chorionic plate vessels and severe villous edema (Arch Pathol Lab Med 1998;122:1091)

End of Placenta > Placental findings in specific newborn/fetal or maternal conditions > Fetal neurologic impairment / cerebral palsy

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