Placental gross/microscopic abnormalities, non-neoplastic
Erythroblastosis (Increased fetal nucleated red blood cells)
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update October 2011
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● Nucleated fetal red blood cells (nRBCs) are common in pre-term placentas but are an abnormal finding in placentas at term
● nRBCs reflect a response to fetal hypoxia or anemia due to a variety of causes including uteroplacental insufficiency, abruption, maternal diabetes, hemolytic disease of the newborn / ABO incompatibility, chronic feto-maternal transfusion, acute blood loss or chromosomal disorders
● Red cells that are smaller than non-nucleated red cells and have round, basophilic nuclei with smooth nuclear surfaces, surrounded by a thin rim of eosinophilic cytoplasm
● The number of cells per 10 hpf is counted
● Grading: mild (cells are easily found in preterm placentae and are rare/occasional at term), moderate (cells easily found at all gestations) and severe (markedly increased cells at all gestations, with at least one in each hpf)
Placental hydropic change accompanied by increased fetal erythroblasts and nucleated RBCs in fetal vessels in villi
End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Erythroblastosis (Increased fetal nucleated red blood cells)
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