Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Placenta

Placental gross/microscopic abnormalities, non-neoplastic

Erythroblastosis (Increased fetal nucleated red blood cells)


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Nucleated fetal red blood cells (nRBCs) are common in pre-term placentas but are an abnormal finding in placentas at term

Etiology
=========================================================================

● nRBCs reflect a response to fetal hypoxia or anemia due to a variety of causes including uteroplacental insufficiency, abruption, maternal diabetes, hemolytic disease of the newborn / ABO incompatibility, chronic feto-maternal transfusion, acute blood loss or chromosomal disorders

Micro description
=========================================================================

● Red cells that are smaller than non-nucleated red cells and have round, basophilic nuclei with smooth nuclear surfaces, surrounded by a thin rim of eosinophilic cytoplasm
● The number of cells per 10 hpf is counted
● Grading: mild (cells are easily found in preterm placentae and are rare/occasional at term), moderate (cells easily found at all gestations) and severe (markedly increased cells at all gestations, with at least one in each hpf)

Micro images
=========================================================================



Placental hydropic change accompanied by increased fetal erythroblasts and nucleated RBCs in fetal vessels in villi

End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Erythroblastosis (Increased fetal nucleated red blood cells)


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).