Placenta
Nonneoplastic placental conditions and abnormalities
Noninfectious
Increased perivillous fibrin
Author: Mandolin S. Ziadie, M.D.
Last author update: 1 October 2011
Last staff update: 10 April 2024
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Increased perivillous fibrin
Cite this page: Ziadie MS. Increased perivillous fibrin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentafibrin.html. Accessed April 24th, 2024.
Definition / general
- Small amounts of fibrin are commonly scattered throughout the normal placenta
- Diffusely increased amounts of perivillous fibrin involving stem and terminal villi and large enough to be grossly visible are a significant pathologic finding
- Increased fibrin may impair gas exchange and lead to growth restriction, oligohydramnious, premature birth (Arch Pathol Lab Med 1994;118:698), neurologic impairment or fetal death
Gross description
- Strands of pale, firm parenchyma
Microscopic (histologic) description
- Abundant perivillous fibrin that obliterates the intervillous space with loss of the syncytiotrophoblast
- Requires at least one area of full thickness involvement / entrapment of at least half of the villi on a single slide
