Nontrophoblastic neoplasms
Giant pigmented nevi of newborn

Topic Completed: 1 November 2011

Revised: 21 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Giant pigmented nevi of newborn "loattrfull text"[sb]

Mandolin S. Ziadie, M.D.
Page views in 2018: 91
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Cite this page: Ziadie MS. Giant pigmented nevi of newborn. website. Accessed September 18th, 2019.
Definition / general
  • Pigmented melanocytes within the placental villi, associated with giant congenital melanocytic nevus of the fetus (see skin - melanocytic tumor)
Microscopic (histologic) description
  • Benign pigmented nevus cells within the villi
  • Although some giant melanocytic nevi can undergo malignant transformation, the benign appearance and lack of vascular involvement favors a congenital rather than a metastatic process
  • Differential diagnosis includes metastatic melanoma of maternal or fetal origin (atypical cells with vascular involvement)
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