Giant pigmented nevi of newborn
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 29 November 2011, last major update November 2011
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● Pigmented melanocytes within the placental villi, associated with giant congenital melanocytic nevus of the fetus (see Skin-Melanocytic Tumors)
● Benign pigmented nevus cells within the villi
● Although some giant melanocytic nevi can undergo malignant transformation, the benign appearance and lack of vascular involvement favors a congenital rather than a metastatic process
● Differential diagnosis includes metastatic melanoma of maternal or fetal origin (atypical cells with vascular involvement)
End of Placenta > Non-trophoblastic neoplasms > Giant pigmented nevi of newborn
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