Placenta
Nonneoplastic placental conditions and abnormalities
Noninfectious
Hemorrhagic endovasculitis / vasculopathy
Author: Mandolin S. Ziadie, M.D.
Last author update: 1 October 2011
Last staff update: 31 August 2020
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Hemorrhagic endovasculitis vasculopathy
Table of Contents
Definition / general | Microscopic (histologic) description | Additional referencesCite this page: Ziadie MS. Hemorrhagic endovasculitis / vasculopathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentahemorrhagicendo.html. Accessed April 24th, 2024.
Definition / general
- Endothelial injury with vascular necrosis
- Existence as a separate lesion from fetal thrombotic vasculopathy (FTV) is debated by some
- Associated with maternal hypertension, fetal neurologic injury, growth restriction, tissue hypoxia and increased perinatal morbidity / mortality
- Etiology is unknown
Microscopic (histologic) description
- Vascular wall injury with extravasated red cells, endothelial / medial hyperplasia, red cell fragmentation and hemosiderin deposition
- Changes similar to intrauterine fetal demise but are focal rather than diffuse
- May be accompanied by chronic villitis, chorionic vascular thrombosis, erythroblastosis, villous fibrosis, infarction and evidence of meconium exposure
Additional references
