Placental gross / microscopic abnormalities, nonneoplastic
Hemorrhagic endovasculitis / vasculopathy

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 13 October 2017, last major update October 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Hemorrhagic endovasculitis vasculopathy

Cite this page: Ziadie, M. Hemorrhagic endovasculitis / vasculopathy. website. Accessed November 18th, 2018.
Definition / general
  • Endothelial injury with vascular necrosis
  • Existence as a separate lesion from fetal thrombotic vasculopathy (FTV) is debated by some
  • Associated with maternal hypertension, fetal neurologic injury, growth restriction, tissue hypoxia and increased perinatal morbidity / mortality
  • Etiology is unknown
Microscopic (histologic) description
  • Vascular wall injury with extravasated red cells, endothelial / medial hyperplasia, red cell fragmentation and hemosiderin deposition
  • Changes similar to intrauterine fetal demise but are focal rather than diffuse
  • May be accompanied by chronic villitis, chorionic vascular thrombosis, erythroblastosis, villous fibrosis, infarction and evidence of meconium exposure
Microscopic (histologic) images

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Hemorrhagic endovasculitis