Placental gross/microscopic abnormalities, non-neoplastic
Hemorrhagic endovasculitis / vasculopathy
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 13 November 2011, last major update October 2011
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● Endothelial injury with vascular necrosis
● Existence as a separate lesion from fetal thrombotic vasculopathy (FTV) is debated by some
● Associated with maternal hypertension, fetal neurologic injury, growth restriction, tissue hypoxia and increased perinatal morbidity / mortality
● Etiology is unknown
● Vascular wall injury with extravasated red cells, endothelial / medial hyperplasia, red cell fragmentation and hemosiderin deposition
● Changes similar to intrauterine fetal demise, but are focal rather than diffuse
● May be accompanied by chronic villitis, chorionic vascular thrombosis, erythroblastosis, villous fibrosis, infarction and evidence of meconium exposure
● Arch Pathol Lab Med 2002;126:157, Arch Pathol Lab Med 1980;104:371
End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Hemorrhagic endovasculitis / vasculopathy
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