Placental gross / microscopic abnormalities, nonneoplastic
Hemorrhagic endovasculitis / vasculopathy

Topic Completed: 1 October 2011

Minor changes: 18 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Hemorrhagic endovasculitis vasculopathy

Mandolin S. Ziadie, M.D.
Page views in 2019: 544
Page views in 2020 to date: 282
Cite this page: Ziadie MS. Hemorrhagic endovasculitis / vasculopathy. website. Accessed June 4th, 2020.
Definition / general
  • Endothelial injury with vascular necrosis
  • Existence as a separate lesion from fetal thrombotic vasculopathy (FTV) is debated by some
  • Associated with maternal hypertension, fetal neurologic injury, growth restriction, tissue hypoxia and increased perinatal morbidity / mortality
  • Etiology is unknown
Microscopic (histologic) description
  • Vascular wall injury with extravasated red cells, endothelial / medial hyperplasia, red cell fragmentation and hemosiderin deposition
  • Changes similar to intrauterine fetal demise but are focal rather than diffuse
  • May be accompanied by chronic villitis, chorionic vascular thrombosis, erythroblastosis, villous fibrosis, infarction and evidence of meconium exposure
Microscopic (histologic) images

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Hemorrhagic endovasculitis

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