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Placenta

Gestational trophoblastic disease

Hydatidiform mole, general


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 December 2011, last major update December 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Abnormal fertilization resulting in an abnormal placenta due to excess paternal genes
● No fetus is formed with a complete mole (diploid); partial moles (triploid) may have fetal tissue
● Most common form of gestational trophoblastic disease; occurs in 1 / 1,000-2,000 pregnancies
Risk factors: history of prior mole, primigravid state, southeast Asian / African / Latin American origin, extremes of reproductive age, Vitamin A-precursor deficiency

Treatment
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● Curettage or hysterectomy

End of Placenta > Gestational trophoblastic disease > Hydatidiform mole, general


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