Gestational trophoblastic disease
Hydatidiform mole

Topic Completed: 1 August 2017

Minor changes: 30 October 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Placenta hydatidiform mole[title]

Sonali Lanjewar, M.B.B.S.
Raavi Gupta, M.D.
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Cite this page: Lanjewar S, Gupta R. Hydatidiform mole. website. Accessed August 12th, 2020.
  • Risk factors: history of prior mole, primigravid state, southeast Asian / African / Latin American origin, extremes of reproductive age and Vitamin A precursor deficiency
Clinical features
  • Hydatidiform mole is an abnormal placenta characterized by enlarged, edematous and vesicular chorionic villi accompanied by villous trophoblastic hyperplasia
  • Frequency of hydatidiform moles is higher in Asia and Middle East (100 - 1000/100,000 pregnancies) compared to North America and Europe (100 per 100,000 pregnancies) (Lancet Oncol 2003;4:670)
  • Hydatidiform mole is subdivided into complete and partial hydatidiform mole based on morphologic, cytogenetic and clinicopathological features
  • All molar pregnancies have the potential for persistent GTD (Lancet Oncol 2003;4:670)
  • Complete moles outnumber partial moles in frequency (Am J Surg Pathol 2008;32:445, Am J Obstet Gynecol 2007;196:172.e1) and carry a higher risk of gestational trophoblastic disease
  • Surgical curettage is the preferred mode of treatment
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