Reviewer: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 23 November 2011, last major update November 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Most severe fetal inflammatory response to intrauterine infection
● Stillbirth is common
● Syphilis (11%), HSV, Candida and prolonged infections
● Also prolonged rupture of membranes (62%), preterm labor
● Also associated with chronic villitis (58%), acute chorioamnionitis (100%, Hum Pathol 1992;23:1278)
● Due to formation of immune complexes within the cord
● When calcified, are yellow-white bands between the umbilical vessels and the cord surface
● Perivascular concentric rings of neutrophils and debris around one or more vessels
● May be associated with dystrophic calcification or neovascularization
● A similar degree of inflammation is present in the chorionic plate vessels
End of Placenta > Umbilical cord > Necrotizing funisitis
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).