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Placenta

Umbilical cord

Necrotizing funisitis


Reviewer: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 23 November 2011, last major update November 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Most severe fetal inflammatory response to intrauterine infection
● Stillbirth is common

Etiology
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● Syphilis (11%), HSV, Candida and prolonged infections
● Also prolonged rupture of membranes (62%), preterm labor
● Also associated with chronic villitis (58%), acute chorioamnionitis (100%, Hum Pathol 1992;23:1278)
● Due to formation of immune complexes within the cord

Gross description
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● When calcified, are yellow-white bands between the umbilical vessels and the cord surface

Micro description
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● Perivascular concentric rings of neutrophils and debris around one or more vessels
● May be associated with dystrophic calcification or neovascularization
● A similar degree of inflammation is present in the chorionic plate vessels

End of Placenta > Umbilical cord > Necrotizing funisitis


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