Placental gross/microscopic abnormalities, non-neoplastic
Large for gestational age / overweight placentas
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 15 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Placenta weight > 90th percentile for estimated gestational age
● Usually due to edema as a result of fetal or maternal factors
● Fetal factors: acute antenatal hypoxia including low Apgar scores, respiratory distress syndrome, neurologic abnormalities (may persist), hydrops/neonatal death (erythroblastosis fetalis, tumors or fetal renal vein thrombosis), chronic intrauterine infection, immunohemolytic anemia, fetomaternal hemorrhage and polyhydramnios (Hum Pathol 1987;18:387)
● Maternal factors: diabetes, anemia, malnutrition, retroplacental hematoma and TORCH infections
● Bulky, overweight placenta
● May include extensive villous edema, chorangiosis and villous dysmaturity (distal villous hypoplasia)
End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Large for gestational age / overweight placentas
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