Placenta
Placental gross / microscopic abnormalities, nonneoplastic
Large for gestational age / overweight placentas

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 13 October 2017, last major update October 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Large for gestational age placenta [title]

Cite this page: Ziadie, M. Large for gestational age / overweight placentas. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentaoverweightpla.html. Accessed December 12th, 2017.
Definition / general
  • Placenta weight > 90th percentile for estimated gestational age
Etiology
  • Usually due to edema as a result of fetal or maternal factors
  • Fetal factors: acute antenatal hypoxia, including low Apgar scores, respiratory distress syndrome, neurologic abnormalities (may persist), hydrops / neonatal death (erythroblastosis fetalis, tumors or fetal renal vein thrombosis), chronic intrauterine infection, immunohemolytic anemia, fetomaternal hemorrhage and polyhydramnios (Hum Pathol 1987;18:387)
  • Maternal factors: diabetes, anemia, malnutrition, retroplacental hematoma and TORCH infections
Gross description
  • Bulky, overweight placenta
Microscopic (histologic) description
  • May include extensive villous edema, chorangiosis and villous dysmaturity (distal villous hypoplasia)