Placenta
Placental gross / microscopic abnormalities, nonneoplastic
Large for gestational age / overweight placentas


Topic Completed: 1 October 2011

Revised: 18 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Large for gestational age placenta [title]

Mandolin S. Ziadie, M.D.
Page views in 2018: 525
Page views in 2019 to date: 497
Cite this page: Ziadie MS. Large for gestational age / overweight placentas. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentaoverweightpla.html. Accessed September 23rd, 2019.
Definition / general
  • Placenta weight > 90th percentile for estimated gestational age
Etiology
  • Usually due to edema as a result of fetal or maternal factors
  • Fetal factors: acute antenatal hypoxia, including low Apgar scores, respiratory distress syndrome, neurologic abnormalities (may persist), hydrops / neonatal death (erythroblastosis fetalis, tumors or fetal renal vein thrombosis), chronic intrauterine infection, immunohemolytic anemia, fetomaternal hemorrhage and polyhydramnios (Hum Pathol 1987;18:387)
  • Maternal factors: diabetes, anemia, malnutrition, retroplacental hematoma and TORCH infections
Gross description
  • Bulky, overweight placenta
Microscopic (histologic) description
  • May include extensive villous edema, chorangiosis and villous dysmaturity (distal villous hypoplasia)
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