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Placenta

Placental findings in specific newborn/fetal or maternal conditions

Recurrent fetal loss

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 17 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Etiology
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● Most common causes of intrauterine fetal death are genetic, infection, thrombotic disorders and autoimmune disease
● Other causes include environmental (smoking, alcohol) and endocrine (diabetes)
● Rate of occurrence varies based on gestational age
● Early recurrent loss is generally due to genetic abnormalities; late loss is more often associated with infection / inflammation
● First trimester: genetic (aneuploidy and other chromosomal abnormalities), thrombophilic and autoimmune
● Second and third trimester: autoimmune (antiphospholipid syndrome), uterine anatomic abnormalities (polyps, leiomyomas, septae, cervical incompetence, etc), maternal hypertension, thrombophilia and infection / inflammation

End of Placenta > Placental findings in specific newborn/fetal or maternal conditions > Recurrent fetal loss

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