Placenta
Placental findings in specific newborn / fetal or maternal conditions
Recurrent fetal loss

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 16 October 2017, last major update October 2011

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PubMed Search: Recurrent fetal loss placenta

Table of Contents
Etiology
Cite this page: Ziadie, M. Recurrent fetal loss. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentarecurrentfetalloss.html. Accessed October 17th, 2017.
Etiology
  • Most common causes of intrauterine fetal death are genetic, infection, thrombotic disorders and autoimmune disease
  • Other causes include environmental (smoking, alcohol) and endocrine (diabetes)
  • Rate of occurrence varies based on gestational age
  • Early recurrent loss is generally due to genetic abnormalities; late loss is more often associated with infection / inflammation
  • First trimester: genetic (aneuploidy and other chromosomal abnormalities), thrombophilic and autoimmune
  • Second and third trimester: autoimmune (antiphospholipid syndrome), uterine anatomic abnormalities (polyps, leiomyomas, septae, cervical incompetence, etc.), maternal hypertension, thrombophilia and infection / inflammation