Table of ContentsEtiology
Cite this page: Ziadie, M. Recurrent fetal loss. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentarecurrentfetalloss.html. Accessed February 19th, 2018.
- Most common causes of intrauterine fetal death are genetic, infection, thrombotic disorders and autoimmune disease
- Other causes include environmental (smoking, alcohol) and endocrine (diabetes)
- Rate of occurrence varies based on gestational age
- Early recurrent loss is generally due to genetic abnormalities; late loss is more often associated with infection / inflammation
- First trimester: genetic (aneuploidy and other chromosomal abnormalities), thrombophilic and autoimmune
- Second and third trimester: autoimmune (antiphospholipid syndrome), uterine anatomic abnormalities (polyps, leiomyomas, septae, cervical incompetence, etc.), maternal hypertension, thrombophilia and infection / inflammation