Placental findings in specific newborn / fetal or maternal conditions
Sickle cell disease

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 16 October 2017, last major update October 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sickle cell disease placenta

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Cite this page: Ziadie, M. Sickle cell disease. website. Accessed January 19th, 2019.
Definition / general
  • Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction
Case reports
Microscopic (histologic) description
  • Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis
Microscopic (histologic) images

Images hosted on other servers:

Many of the maternal
red blood cells in
this placenta are
sickle shaped

Electron microscopy description
  • Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis reduplication of inner elastic lamina (Hum Pathol 1999;30:13)