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Placenta
Specific Fetal and Maternal Conditions
Sickle Cell Disease
Reviewers: Mandolin Ziadie, M.D., (see Reviewers page)
Revised: 12 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
Definition
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● Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction
Case report
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● 28 year old woman with sickle cell trait (Arch Pathol Lab Med 2000;124:1565)
Micro description (Histopathology)
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● Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis
Micro images
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Many of the maternal red blood cells in this placenta are sickle shaped
Electron microscopy description
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● Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis
reduplication of inner elastic lamina (Hum Pathol 1999;30:13)
End of Placenta > Specific Fetal and Maternal Conditions > Sickle Cell Disease
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