Placental findings in specific newborn / fetal or maternal conditions
Sickle cell disease

Topic Completed: 1 October 2011

Minor changes: 19 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Sickle cell disease placenta

Mandolin S. Ziadie, M.D.
Page views in 2019: 451
Page views in 2020 to date: 199
Cite this page: Ziadie MS. Sickle cell disease. website. Accessed June 1st, 2020.
Definition / general
  • Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction
Case reports
Microscopic (histologic) description
  • Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis
Microscopic (histologic) images

Images hosted on other servers:

Many of the maternal
red blood cells in
this placenta are
sickle shaped

Electron microscopy description
  • Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis reduplication of inner elastic lamina (Hum Pathol 1999;30:13)
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