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Placenta

Placental findings in specific newborn/fetal or maternal conditions

Fetal trisomies

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 17 November 2011, last major update November 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Gross description
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● A single umbilical artery is more common in trisomic pregnancies
● Early spontaneous abortions may show no fetal parts and an absent umbilical cord (Hum Pathol 1995;26:201)

Laboratory findings
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● Trisomy 21: elevated serum hcG and inhibin, reduced serum estradiol and AFP
● Trisomy 18: low serum hcG, low AFP, low inhibin and low estradiol

Micro description
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● Large hypovascular / avascular villi with irregular borders accompanied by normal-appearing villi
● Villous hydrops is also seen, though less than in other abnormal karyotypes

End of Placenta > Placental findings in specific newborn/fetal or maternal conditions > Fetal trisomies

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