Placenta
Placental findings in specific newborn / fetal or maternal conditions
Fetal trisomies

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 16 October 2017, last major update November 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Fetal trisomies placenta[title]

Cite this page: Ziadie, M. Fetal trisomies. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentatrisomy.html. Accessed November 24th, 2017.
Laboratory
  • Trisomy 21: elevated serum hcG and inhibin, reduced serum estradiol and AFP
  • Trisomy 18: low serum hcG, low AFP, low inhibin and low estradiol
Gross description
  • Single umbilical artery is more common in trisomic pregnancies
  • Early spontaneous abortions may show no fetal parts and an absent umbilical cord (Hum Pathol 1995;26:201)
Microscopic (histologic) description
  • Large hypovascular / avascular villi with irregular borders accompanied by normal appearing villi
  • Villous hydrops is also seen though less than in other abnormal karyotypes