Placental findings in specific newborn/fetal or maternal conditions
Fetal trisomies

Topic Completed: 1 November 2011

Minor changes: 19 February 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Fetal trisomies placenta[title]

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Fetal trisomies. website. Accessed September 24th, 2020.
  • Trisomy 21: elevated serum hcG and inhibin, reduced serum estradiol and AFP
  • Trisomy 18: low serum hcG, low AFP, low inhibin and low estradiol
Gross description
  • Single umbilical artery is more common in trisomic pregnancies
  • Early spontaneous abortions may show no fetal parts and an absent umbilical cord (Hum Pathol 1995;26:201)
Microscopic (histologic) description
  • Large hypovascular / avascular villi with irregular borders accompanied by normal appearing villi
  • Villous hydrops is also seen though less than in other abnormal karyotypes
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