Mesothelial tumors
Mesothelioma - desmoplastic

Topic Completed: 1 November 2013

Revised: 2 October 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Desmoplastic mesothelioma

See Also: Mesothelioma

Vaidehi Avadhani, M.D.
Page views in 2018: 950
Page views in 2019 to date: 866
Cite this page: Avadhani V. Mesothelioma - desmoplastic. website. Accessed October 13th, 2019.
Definition / general
  • > 50% of tumor shows desmoplastic pattern
  • 5 - 10% of malignant mesotheliomas
  • Note: DMM may refer to desmoplastic or diffuse malignant mesothelioma
Case reports
Microscopic (histologic) description
  • Characteristic dense collagenized tissue separated by atypical cells arranged in a storiform or haphazard pattern (J Clin Pathol 1992;45:295), comprising > 50% of tumor
  • Presence of sarcomatoid areas, bland collagen, necrosis, stromal / fat invasion help differentiate from organizing pleuritis (Am J Surg Pathol 2011;35:1823)
  • Paucicellularity of lesion may lead to misdiagnosis
Microscopic (histologic) images

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Storiform pattern

Figures 5A / 5B

Positive stains
Negative stains
  • CD31 (positive in angiosarcoma), CD34 (positive in solitary fibrous tumor, Hum Pathol 1995;26:428)
  • S100 (positive in neurogenic tumors, mesotheliomas may show focal staining)
  • CD45
  • Some muscle markers are focally positive
Electron microscopy description
  • Sarcomatous mesotheliomas including desmoplastic type have no specific ultrastructural features
Differential diagnosis
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