Pleura
Mesothelial tumors
Mesothelioma - desmoplastic

Author: Vaidehi Avadhani, M.D. (see Authors page)

Revised: 23 March 2018, last major update November 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Desmoplastic mesothelioma

See also: Mesothelioma
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Cite this page: Avadhani, V. Mesothelioma - desmoplastic. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pleuramesotheliomadesmoplastic.html. Accessed August 22nd, 2019.
Definition / general
  • > 50% of tumor shows desmoplastic pattern
  • 5 - 10% of malignant mesotheliomas
  • Note: DMM may refer to desmoplastic or diffuse malignant mesothelioma
Case reports
Microscopic (histologic) description
  • Characteristic dense collagenized tissue separated by atypical cells arranged in a storiform or haphazard pattern (J Clin Pathol 1992;45:295), comprising > 50% of tumor
  • Presence of sarcomatoid areas, bland collagen, necrosis, stromal / fat invasion help differentiate from organizing pleuritis (Am J Surg Pathol 2011;35:1823)
  • Paucicellularity of lesion may lead to misdiagnosis
Microscopic (histologic) images

Images hosted on other servers:

Storiform pattern

Figures 5A / 5B

Positive stains
Negative stains
  • CD31 (positive in angiosarcoma), CD34 (positive in solitary fibrous tumor, Hum Pathol 1995;26:428)
  • S100 (positive in neurogenic tumors, mesotheliomas may show focal staining)
  • CD45
  • Some muscle markers are focally positive
Electron microscopy description
  • Sarcomatous mesotheliomas including desmoplastic type have no specific ultrastructural features
Differential diagnosis
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