Pleura & peritoneum
Pleura mesothelial tumors
Mesothelioma-biphasic
Author: Vaidehi Avadhani, M.D.
Last author update: 1 November 2013
Last staff update: 11 January 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Biphasic mesothelioma pleura
See Also: Mesothelioma
Table of Contents
Definition / general | Epidemiology | Radiology images | Case reports | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Avadhani V. Mesothelioma-biphasic. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/pleuramesotheliomamixed.html. Accessed April 20th, 2024.
Definition / general
- Biphasic / mixed: both epithelioid and sarcomatoid components, each at least 10%
- May represent epithelial mesenchymal transition process (Mod Pathol 2012;25:86)
Epidemiology
- Biphasic pattern occurs in 30%, less common than epithelioid variant but more common than the pure sarcomatoid variant
Radiology images
Images hosted on other servers:
Low density mass in liver
Case reports
- 66 year old man with hepatic nodule (World J Gastroenterol 2009;15:615)
Gross images
Images hosted on other servers:
Firm, white lesion
Microscopic (histologic) description
- Epithelioid and sarcomatoid areas, juxtaposed to each other or intermingled
Microscopic (histologic) images
Images hosted on other servers:
Biphasic tumor
H&E and immunostains
Various stains
Differential diagnosis
- Metastatic pleomorphic carcinoma, most commonly from lung
- Reactive proliferation in response to serosal metastases
- Synovial sarcoma
