Pleura & peritoneum
Pleura mesothelial tumors
Mesothelioma-biphasic


Topic Completed: 1 November 2013

Minor changes: 13 July 2020

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PubMed Search: Biphasic mesothelioma pleura

See Also: Mesothelioma

Vaidehi Avadhani, M.D.
Page views in 2019: 398
Page views in 2020 to date: 567
Cite this page: Avadhani V. Mesothelioma-biphasic. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pleuramesotheliomamixed.html. Accessed August 3rd, 2020.
Definition / general
  • Biphasic / mixed: both epithelioid and sarcomatoid components, each at least 10%
  • May represent epithelial mesenchymal transition process (Mod Pathol 2012;25:86)
Epidemiology
  • Biphasic pattern occurs in 30%, less common than epithelioid variant but more common than the pure sarcomatoid variant
Radiology images

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Low density mass in liver

Case reports
Gross images

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Firm, white lesion

Microscopic (histologic) description
  • Epithelioid and sarcomatoid areas, juxtaposed to each other or intermingled
Microscopic (histologic) images

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Biphasic tumor

H&E and immunostains

Various stains

Differential diagnosis
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