Pleura
Mesothelial tumors
Mesothelioma - mixed


Topic Completed: 1 November 2013

Revised: 2 October 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Mixed mesothelioma pleura

See Also: Mesothelioma

Vaidehi Avadhani, M.D.
Page views in 2018: 294
Page views in 2019 to date: 340
Cite this page: Avadhani V. Mesothelioma - mixed. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pleuramesotheliomamixed.html. Accessed December 10th, 2019.
Definition / general
  • Mixed / biphasic: both epithelioid and sarcomatoid components, each at least 10%
  • May represent epithelial mesenchymal transition process (Mod Pathol 2012;25:86)
Epidemiology
  • Biphasic pattern occurs in 30%, less common than epithelioid variant but more common than the pure sarcomatoid variant
Radiology images

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Low density mass in liver

Case reports
Gross images

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Firm, white lesion

Microscopic (histologic) description
  • Epithelioid and sarcomatoid areas, juxtaposed to each other or intermingled
Microscopic (histologic) images

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Biphasic tumor

H&E and immunostains

Various stains

Differential diagnosis
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