Pleura
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Nodular histiocytic hyperplasia


Topic Completed: 1 May 2014

Revised: 1 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Nodular histiocytic hyperplasia
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Cite this page: Avadhani V. Nodular histiocytic hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pleuranodularhistiohyper.html. Accessed May 25th, 2019.
Definition / general
  • Small nodular aggregates of histiocytes with mesothelial cells scattered in the aggregates or in clusters
Terminology
  • Nodular mesothelial hyperplasia, mesothelial / monoytc incidental cardiac excrescences (MICE), nodular histiocytic / mesothelial hyperplasia
Sites
  • Lesions have been described in lung, pleura, hernia sac, pericardium, peritoneum
Pathophysiology
  • Hypothesis: trauma, tumor or inflammation lead to histiocyte / mesothelial expression of CD34 and adhesion molecules, which lead to aggregates of histiocytes and mesothelial cells through cell-cell interactions
Clinical features
  • Almost always an incidental finding
Case reports
Treatment
  • None required; an incidental finding
Clinical images

Images hosted on other servers:

Pericardial nodule over arch of aorta

Microscopic (histologic) description
  • Compact nodular collections of polygonal to oval cells with indistinct cell borders and moderate cytoplasm
  • Nuclei are oval to angulated with grooves (usually) and inconspicuous nucleoli
  • Mitoses may be present but no atypical mitoses
  • Hemosiderin laden macrophages may be present
  • Also present are scattered indistinguishable bland cuboidal to polygonal cells with moderate cytoplasm, which show cytokeratin and calretinin staining, indicating their mesothelial origin
Microscopic (histologic) images

Images hosted on other servers:

Hernial sac: H&E, CD68, CD1a

Pericardium

Pericardium: vimentin+, CD68+, S100+

Cytology description
  • Similar nodular aggregates have also been described in cell block material from serous effusions - this is the most important pitfall in cytodiagnosis of serous effusions (Diagn Cytopathol 2002;26:68)
Positive stains
Negative stains
Differential diagnosis
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