Other tumors
Synovial sarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 March 2018, last major update December 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Synovial sarcoma pleura

Cite this page: Pernick, N. Synovial sarcoma. website. Accessed September 22nd, 2018.
Definition / general
  • Very rare, < 20 cases reported
  • Usually represents metastatic disease from extremity
  • Mean age 47 years
  • Chest pain, pleural masses, pleural effusions
Case reports
Gross description
  • Soft, friable, gray cut surface with solid and cystic areas, focal hemorrhage, myxoid change
Microscopic (histologic) description
  • Biphasic or monophasic
  • Dense, spindle cells in fascicles with mild pleomorphic oval nuclei, focally less cellular areas
  • May have hemangiopericytoma-like vessels, myxoid areas
  • Mild atypia, frequent mitotic activity
  • Monophasic cases lack epithelial differentiation
Microscopic (histologic) images

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Cytology description
  • Spindle cells with scant cytoplasm with cytoplasmic processes, uniform oval nuclei, fine chromatin, inconspicuous nucleoli
  • Branching blood vessels
Positive stains
Negative stains
Molecular / cytogenetics description
  • SYT-SSX1 or SYT-SSX2 fusion transcript due to t(X;18)(p11.2;q11.2)
Molecular / cytogenetics images

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