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Prostate

Other malignancies

PEComa

Reviewer: Komal Arora, M.D., (see Reviewers page)
Revised: 26 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Perivascular epithelioid cell tumors (PEComas) include clear cell “sugar” tumor of lung, lymphangioleiomyomatosis, angiomyolipoma (see Soft Tissue chapter)

Case reports
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● 46 year old man with malignant PEComa involving prostate and seminal vesicle (Arch Pathol Lab Med 2003;127:E96)

Micro description
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● Epithelioid cells with clear/granular cytoplasm in perivascular distribution

Micro images
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Various images

Positive stains
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● HMB45, variable MelanA/MART1

Negative stains
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● Keratin, S100

Electron microscopy description
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● May have premelanosomes

Electron microscopy images
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Malignant PEComa

Differential diagnosis
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● Clear cell sarcoma of soft parts: no vascular stroma, no perivascular arrangement of tumor cells, S100+

End of Prostate > Other malignancies > PEComa

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