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Prostate

Other carcinomas

Adenoid basal cell tumor


Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 19 March 2012, last major update February 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also known as adenoid cystic-like tumor, basal cell carcinoma, adenoid basal proliferation of uncertain significance
● Resembles to some extent the salivary gland tumor
● Usually indolent; cases with aggressive behavior often have large solid nests with central necrosis, high Ki67%, less staining with basal cell markers (Am J Surg Pathol 2007;31:697)

Case reports
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● 67 year old man (Int J Clin Oncol 2010;15:594)

Micro description
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● Expansive (not circumscribed) growth pattern
● Multinodular, basaloid cells in clusters, some with punched out lumens
● Surrounding fibromyxoid stroma, squamous differentiation, merges with basal cell hyperplasia
● May be associated with minor component of usual type prostatic adenocarcinoma
● Considered malignant if extensive infiltration between normal prostate gland, extension out of the prostate, perineural invasion, necrosis or metastases
● Gleason grading of these tumors is not recommended

Micro images
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Various images

Postive stains
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● 34betaE12
● p63

Negative stains
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● PSA/PAP

Case reports
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Arch Pathol Lab Med 1993;117:799, Am J Clin Pathol 1988;89:49

End of Prostate > Other carcinomas > Adenoid basal cell tumor


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