Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 2 June 2012, last major update June 2012
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● Rare in prostate, < 20 cases reported
● Criteria for radiation-induced sarcoma: arise in area previously radiated, latent period (in years), sarcoma confirmed histologically (Cancer 1948;1:3)
● Association with radiation therapy may be weak (BJU Int 2012 May 15 [Epub ahead of print])
● 79 year old man with tumor 10 years after radiotherapy for prostatic adenocarcinoma (Arch Pathol Lab Med 2003;127:876)
● Angiosarcoma as component of immature prostatic teratoma (Int J Urol 2006;13:305)
● Extensive necrosis
● Proliferative vascular channels lined by atypical, multilayered or solid endothelial cells
● Tumor cells pleomorphic, varying from spindled to large/plump
● Large pleomorphic nuclei with clumped chromatin and prominent nucleoli
● Frequent mitotic figures, some atypical
Bladder cases (no prostate involvement)
● CD34, Factor 8, vimentin
● PSA, S100, keratin
End of Prostate > Other malignancies > Angiosarcoma
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