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Prostate

Other malignancies

Angiosarcoma


Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 2 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare in prostate, < 20 cases reported
● Criteria for radiation-induced sarcoma: arise in area previously radiated, latent period (in years), sarcoma confirmed histologically (Cancer 1948;1:3)
● Association with radiation therapy may be weak (BJU Int 2012 May 15 [Epub ahead of print])

Case reports
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● 79 year old man with tumor 10 years after radiotherapy for prostatic adenocarcinoma (Arch Pathol Lab Med 2003;127:876)
● Angiosarcoma as component of immature prostatic teratoma (Int J Urol 2006;13:305)

Gross description
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● Extensive necrosis

Micro description
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● Proliferative vascular channels lined by atypical, multilayered or solid endothelial cells
● Tumor cells pleomorphic, varying from spindled to large/plump
● Large pleomorphic nuclei with clumped chromatin and prominent nucleoli
● Frequent mitotic figures, some atypical

Micro images
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Various images

   
Bladder cases (no prostate involvement)

Positive stains
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● CD34, Factor 8, vimentin

Negative stains
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● PSA, S100, keratin

End of Prostate > Other malignancies > Angiosarcoma


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