Prostate
Other malignancies
Angiosarcoma

Authors: Komal Arora, M.D. (see Authors page)

Revised: 24 August 2016, last major update June 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: prostatic angiosarcoma
Definition / General
  • Rare in prostate, < 20 cases reported
  • Criteria for radiation-induced sarcoma: arise in area previously radiated, latent period (in years), sarcoma confirmed histologically (Cancer 1948;1:3)
  • Association with radiation therapy may be weak (BJU Int 2012;110:E819)
Case Reports
Gross Description
  • Extensive necrosis
Micro Description
  • Proliferative vascular channels lined by atypical, multilayered or solid endothelial cells
  • Tumor cells pleomorphic, varying from spindled to large/plump
  • Large pleomorphic nuclei with clumped chromatin and prominent nucleoli
  • Frequent mitotic figures, some atypical
Micro Images

Images hosted on other servers:

Various images

Bladder cases (no prostate involvement)

Positive Stains
  • CD34, Factor 8, vimentin
Negative Stains
  • PSA, S100, keratin