Prostate
Prostatic carcinoma variants
Atrophic adenocarcinoma

Authors: Komal Arora, M.D. (see Authors page)

Revised: 8 August 2016, last major update March 2012

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PubMed search: prostatic atrophic adenocarcinoma
Definition / General
  • Proliferation of malignant acini that architecturally resembles atrophy or post-atrophic hyperplasia but retains the diagnostic cytologic features of cancer
  • Usually NOT associated with hormone therapy
Micro Description
  • Acini are round, often dilated and distorted and lined by flattened attenuated epithelium with scant cytoplasm and infiltrative growth pattern
  • Nuclear enlargement and prominent nucleoli present
  • Atrophic features represent mean 25% of total tumor (range 10-90%) in needle biopsies and prostatectomy specimens
  • Usually Gleason score 6-7 (Am J Surg Pathol 1997;21:289, Am J Clin Pathol 1998;109:695)
  • Also luminal eosinophilic proteinaceous secretions, blue mucin, crystalloids, apocrine blebs, collagenous micronodules, high-grade PIN within two high-power fields (Am J Surg Pathol 1997;21:931)
Micro Images

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Various images

Differential Diagnosis
  • Benign atrophy: no associated carcinoma, small and indistinct nucleoli, basal layer present but may be fragmented