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Prostatic carcinoma variants

Atrophic adenocarcinoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Proliferation of malignant acini that architecturally resembles atrophy or postatrophic hyperplasia but retains the diagnostic cytologic features of cancer
● Usually NOT associated with hormone therapy

Micro description

● Acini are round, often dilated and distorted and lined by flattened attenuated epithelium with scant cytoplasm and infiltrative growth pattern
● Nuclear enlargement and prominent nucleoli present
● Atrophic features represent mean 25% of total tumor (range 10-90%) in needle biopsies and prostatectomy specimens
● Usually Gleason score 6-7 (Am J Surg Pathol 1997;21:289, Am J Clin Pathol 1998;109:695)
● Also luminal eosinophilic proteinaceous secretions, blue mucin, crystalloids, apocrine blebs, collagenous micronodules, high-grade PIN within two high-power fields (Am J Surg Pathol 1997;21:931)

Micro images

Various images

Differential diagnosis

Benign atrophy: no associated carcinoma, small and indistinct nucleoli, basal layer present but may be fragmented

End of Prostate > Other carcinomas > Atrophic adenocarcinoma

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