Prostate
Microscopic mimics of prostatic carcinoma
Basal cell hyperplasia with prominent nucleoli

Author: Andres Matoso, M.D. (see Authors page)

Revised: 1 June 2016, last major update May 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Basal cell hyperplasia with prominent nucleoli

Related topics: Basal cell hyperplasia and Florid basal cell hyperplasia

Cite this page: Basal cell hyperplasia with prominent nucleoli. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatebchnucleoli.html. Accessed June 26th, 2017.
Definition / general
Terminology
  • Formerly called atypical basal cell hyperplasia
Epidemiology
  • 2% incidence in needle core biopsies
Sites
  • More common in the transition zone; can be present in the peripheral zone
Pathophysiology
  • Unknown
Etiology
  • Unknown
Prognostic factors
  • Not associated with increased risk of cancer
Treatment
  • Not required
Microscopic (histologic) description
  • Nuclear enlargement, hyperchromasia, prominent nucleoli, mitotic figures
Microscopic (histologic) images

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Basal cell hyperplasia with prominent nucleoli

Negative stains
Differential diagnosis
  • Basal cell hyperlasia: can be distinguished from carcinoma by its multilayered nuclei, atrophic cytoplasm, lack of infiltrative growth pattern and positive immunohistochemistry for high molecular weight cytokeratin